Time lapse analysis of tumor response in patients with soft tissue sarcoma treated with trabectedin: A pooled analysis of two phase II clinical trials.,Cancer Medicine

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Time lapse analysis of tumor response in patients with soft tissue sarcoma treated with trabectedin: A pooled analysis of two phase II clinical trials.
Cancer Medicine ( IF 2.9 ) Pub Date : 2020-03-27 , DOI: 10.1002/cam4.2991
Makoto Endo ₁ , Shunji Takahashi ₂ , Nobuhito Araki ₃ , Hideshi Sugiura ₄ , Takafumi Ueda ₅ , Tsukasa Yonemoto ₆ , Mitsuru Takahashi ₇ , Hideo Morioka ₈ , Hiroaki Hiraga ₉ , Toru Hiruma ₁₀ , Toshiyuki Kunisada ₁₁ , Akihiko Matsumine ₁₂ , Kazato Goda ₁₃ , Akira Kawai ₁₄

Affiliation

Department of Orthopaedic Surgery, Kyushu University, Fukuoka, Japan.
Department of Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
Department of Orthopaedic Surgery, Osaka International Cancer Institute, Osaka, Japan.
Department of Physical Therapy, Nagoya University, Nagoya, Japan.
Department of Orthopaedic Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan.
Division of Orthopaedic Surgery, Chiba Cancer Center, Chiba, Japan.
Division of Orthopaedic Surgery, Shizuoka Cancer Center Hospital, Nagaizumi, Japan.
Department of Orthopaedic Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Department of Orthopaedic Surgery, Hokkaido Cancer Center, Sapporo, Japan.
Department of Musculoskeletal Tumor Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Department of Orthopaedic Surgery, Okayama University Hospital, Okayama, Japan.
Department of Orthopaedic Surgery, Fukui University, Fukui, Japan.
Department of Medical affairs, Taiho Pharmaceutical Co. Ltd, Tokyo, Japan.
Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan.

The time course of the response to each drug is important to avoid inappropriate termination of treatment by misjudging tumor progression; however, little is known about soft tissue sarcoma (STS) regarding this matter. This study aimed to perform a time‐lapse analysis of tumor response in patients with STS treated with trabectedin from 2 phase II clinical trials.

中文翻译：

用曲贝替丁治疗的软组织肉瘤患者的肿瘤反应时移分析：两项II期临床试验的汇总分析。

对每种药物的反应时间过程很重要，可以避免通过误判肿瘤的进展避免不适当的治疗终止。然而，关于软组织肉瘤（STS）对此知之甚少。这项研究旨在对2项II期临床试验中用trabectedin治疗的STS患者进行肿瘤反应的时延分析。

更新日期：2020-03-27

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