Catatonia is a psychomotor syndrome defined by a constellation of predominantly motor symptoms. The aim of the present study was to determine whether recently admitted psychiatric patients with catatonia exhibited higher serum C-reactive protein (hs-CRP) levels compared to non-catatonic psychiatric patients and healthy controls (HCs). Recently admitted psychiatric patients were screened and evaluated for the catatonia syndrome using the Bush-Francis Catatonia Rating Scale and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). The study sample was formed by 150 individuals (39 male and 111 female), including 51 catatonic patients, 55 non-catatonic patients, and 44 HCs. Serum hs-CRP levels were processed with the enzyme-linked immunosorbent assay. Serum levels of creatine kinase (CK), adrenocorticotropic hormone (ACTH), immunoglobulin G (IgG), complement component 3 (C3), and complement component 4 (C4) were also determined. There was a significantly higher percentage of patients with high inflammatory levels (hs-CRP > 3000ng/ml) in the catatonic (43.1%) than in the non-catatonic (14.5%) or HCs group (9.1%) (χ ² =18.9, P < .001). Logistic regression showed that catatonic patients had significantly higher hs-CRP levels compared to non-catatonic patients even after controlling for other clinical and laboratory variables (OR = 3.52, P = .015, 95% CI 1.28–9.79). Multiple linear regression analysis revealed that log-transformed hs-CRP was independently predicted by body mass index and log-transformed C4, ACTH, and Cortisol in catatonic patients. Findings of the present study suggest that catatonia is specifically linked to a higher level of systemic inflammation, not merely attributable to the overall psychopathology, or alterations in the stress level and complement system.

中文翻译：

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紧张症患者血清 C 反应蛋白水平较高：与非紧张症患者和健康对照者的比较


紧张症是一种精神运动综合征，由一系列主要运动症状定义。本研究的目的是确定最近入院的紧张症精神病患者与非紧张症精神病患者和健康对照 (HC) 相比是否表现出更高的血清 C 反应蛋白 (hs-CRP) 水平。使用布什-弗朗西斯紧张症评定量表和精神障碍诊断和统计手册第五版（DSM-5）对最近入院的精神病患者进行紧张症综合征筛查和评估。研究样本由 150 人组成（39 名男性和 111 名女性），其中包括 51 名紧张症患者、55 名非紧张症患者和 44 名 HC。血清 hs-CRP 水平采用酶联免疫吸附测定法进行处理。还测定了肌酸激酶 (CK)、促肾上腺皮质激素 (ACTH)、免疫球蛋白 G (IgG)、补体成分 3 (C3) 和补体成分 4 (C4) 的血清水平。紧张症组 (43.1%) 中高炎症水平 (hs-CRP > 3000ng/ml) 的患者比例显着高于非紧张症组 (14.5%) 或 HCs 组 (9.1%) (χ ² =18.9) ， P < .001）。 Logistic 回归显示，即使在控制其他临床和实验室变量后，紧张症患者的 hs-CRP 水平也显着高于非紧张症患者（OR = 3.52， P = .015，95% CI 1.28–9.79）。多元线性回归分析显示，紧张症患者的对数转换 hs-CRP 可以通过体重指数以及对数转换 C4、ACTH 和皮质醇独立预测。 本研究的结果表明，紧张症与较高水平的全身炎症特别相关，而不仅仅是归因于整体精神病理学或应激水平和补体系统的改变。