The purpose of this study is to evaluate the prognostic value of preoperative Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) in predicting overall survival for patients with hepatitis B- and hepatitis C-related early-stage hepatocellular carcinoma (ESHCC) after liver resection. Post-operative survival rates were compared according to WFA+-M2BP level and tumor stage. Six hundred and ten patients were identified and 198 were removed after application of the exclusion criteria; the median follow-up time was 4.33 years, and cancer-related death occurred in 117 (28.4%) patients. Age (p = 0.03), fibrosis grade (p = 0.042), cancer stage (p = 0.01), and WFA+-M2BP level (p = 0.001) were identified as independent risk factors for poor overall survival. The overall survival rates at 3 and 5 years for patients with WFA+-M2BP ≤ 1.12 were 0.92 and 0.90, respectively, and 0.76 and 0.61 for patients with WFA+-M2BP > 1.12 (p < 0.001). During the analysis of survival prediction, serum WFA+-M2BP level exhibited a higher log-likelihood and a lower AIC value compared to TNM stage (log likelihood: −638; AIC: 1279). Pre-operative serum WFA+-M2BP level provided important prognostic information after curative hepatic resection in our study.

这项研究的目的是评估术前紫藤紫花凝集素阳性Mac-2结合蛋白（WFA + -M2BP）在预测乙型肝炎和丙型肝炎相关的早期肝细胞癌（ESHCC）患者的总生存率中的预后价值）肝切除后。根据WFA + -M2BP水平和肿瘤分期比较术后生存率。应用排除标准后，确定了610例患者，并去除了198例；中位随访时间为4.33年，其中117例（28.4％）患者发生了与癌症相关的死亡。年龄（p = 0.03），纤维化等级（p = 0.042），癌症分期（p = 0.01）和WFA + -M2BP水平（p = 0.001）被确定为整体生存不良的独立危险因素。WFA + -M2BP≤1的患者3年和5年的总生存率。WFA + -M2BP> 1.12（p <0.001）的患者分别为12个，分别为0.92和0.90，以及0.76和0.61。在生存预测分析中，与TNM分期相比，血清WFA + -M2BP水平表现出较高的对数似然性和较低的AIC值（对数似然性：−638； AIC：1279）。在我们的研究中，术前血清WFA + -M2BP水平为根治性肝切除术后的重要预后信息提供了依据。