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Prognostic Role of Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Level in Early Stage Hepatocellular Carcinoma.
Scientific Reports ( IF 3.8 ) Pub Date : 2020-03-27 , DOI: 10.1038/s41598-020-62631-6
Joseph Lin,Chih-Jan Ko,Yu-Ju Hung,Ping-Yi Lin,Kuo-Hua Lin,Chia-En Hsieh,Chen-Te Chou,Yao-Li Chen

The purpose of this study is to evaluate the prognostic value of preoperative Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) in predicting overall survival for patients with hepatitis B- and hepatitis C-related early-stage hepatocellular carcinoma (ESHCC) after liver resection. Post-operative survival rates were compared according to WFA+-M2BP level and tumor stage. Six hundred and ten patients were identified and 198 were removed after application of the exclusion criteria; the median follow-up time was 4.33 years, and cancer-related death occurred in 117 (28.4%) patients. Age (p = 0.03), fibrosis grade (p = 0.042), cancer stage (p = 0.01), and WFA+-M2BP level (p = 0.001) were identified as independent risk factors for poor overall survival. The overall survival rates at 3 and 5 years for patients with WFA+-M2BP ≤ 1.12 were 0.92 and 0.90, respectively, and 0.76 and 0.61 for patients with WFA+-M2BP > 1.12 (p < 0.001). During the analysis of survival prediction, serum WFA+-M2BP level exhibited a higher log-likelihood and a lower AIC value compared to TNM stage (log likelihood: −638; AIC: 1279). Pre-operative serum WFA+-M2BP level provided important prognostic information after curative hepatic resection in our study.



中文翻译:

紫藤花粉凝集素阳性的Mac-2结合蛋白水平在早期肝细胞癌中的预后作用。

这项研究的目的是评估术前紫藤紫花凝集素阳性Mac-2结合蛋白(WFA + -M2BP)在预测乙型肝炎和丙型肝炎相关的早期肝细胞癌(ESHCC)患者的总生存率中的预后价值)肝切除后。根据WFA + -M2BP水平和肿瘤分期比较术后生存率。应用排除标准后,确定了610例患者,并去除了198例;中位随访时间为4.33年,其中117例(28.4%)患者发生了与癌症相关的死亡。年龄(p = 0.03),纤维化等级(p = 0.042),癌症分期(p = 0.01)和WFA + -M2BP水平(p = 0.001)被确定为整体生存不良的独立危险因素。WFA + -M2BP≤1的患者3年和5年的总生存率。WFA + -M2BP> 1.12(p <0.001)的患者分别为12个,分别为0.92和0.90,以及0.76和0.61。在生存预测分析中,与TNM分期相比,血清WFA + -M2BP水平表现出较高的对数似然性和较低的AIC值(对数似然性:−638; AIC:1279)。在我们的研究中,术前血清WFA + -M2BP水平为根治性肝切除术后的重要预后信息提供了依据。

更新日期:2020-03-27
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