Design Randomised clinical trial

Study population The present study evaluated patients of different genders aged between 18-65 years old. The study design and the language of the consent form were approved by the Ethics Committee at Tehran University of Medical Sciences (TUMS) (approval code: IR.TUMS.REC.1394.1906). The study was registered in the Iranian Registry of Clinical Trials.

Data Analysis The evaluation was performed using the Heft-Parker Visual Analog Scale (HP VAS) and complemented with the electrical pulp test accuracy to determine the success of anaesthesia

Results In this study, the success rate was 93.8% (95% CI 79.19-99.23) for mental/incisive nerve block (MINB), and 81.2% (95% CI 63.56-92.79) for inferior alveolar nerve block (IANB). The difference was not significant (p = 0.26). An interesting result was the combination of both techniques was 100% successful in the failed cases (2 in MINB group; 6 in IANB group).

Conclusions In conclusion, MINB using 4% Articaine showed a similar success rate as IANB using 4% Articaine in local anaesthesia for mandibular premolars with irreversible pulpitis. The beginning of anaesthesia was faster for MINB, and the injection was painless. The post-injection pain for MINB was higher than for IANB. Both techniques showed similar efficacy.

设计随机临床试验

研究人群本研究评估了18-65岁之间不同性别的患者。研究设计和同意书的语言已获德黑兰医科大学伦理委员会（TUMS）批准（批准代码：IR.TUMS.REC.1394.1906）。该研究已在伊朗临床试验注册中心进行了注册。

数据分析使用Heft-Parker视觉模拟量表（HP VAS）进行评估，并辅以电纸浆测试准确性来确定麻醉是否成功

结果在这项研究中，成功​​的率为93.8％（95％CI 79.19-99.23），适用于精神/尖锐神经阻滞（MINB），以及81.2％（95％CI 63.56-92.79）针对下牙槽神经阻滞（IANB）。差异不显着（p = 0.26）。一个有趣的结果是，两种技术的组合在失败的案例中均成功100％成功（MINB组为2个； IANB组为6个）。

结论总之，在不可逆性牙髓炎的下颌前磨牙局部麻醉中，使用4％青蒿素的MINB与使用4％青蒿素的IANB表现出相似的成功率。MINB的麻醉开始更快，并且注射无痛。MINB的注射后疼痛高于IANB。两种技术均显示出相似的功效。