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Toward Organism-scale Structural Biology: S-layer Reined in by Bacterial LPS.
Trends in Biochemical Sciences ( IF 11.6 ) Pub Date : 2020-03-27 , DOI: 10.1016/j.tibs.2020.03.006 Morgan Beeby 1
中文翻译:
迈向生物规模的结构生物学:细菌LPS抑制了S层。
更新日期:2020-03-27
Trends in Biochemical Sciences ( IF 11.6 ) Pub Date : 2020-03-27 , DOI: 10.1016/j.tibs.2020.03.006 Morgan Beeby 1
Affiliation
Technical developments are unifying molecular and cellular biology. A recent electron cryotomography study by von Kügelgen et al. highlights the bright future for such studies, seamlessly integrating near-atomic resolution protein structures, organism-scale architecture, native mass spectrometry, and molecular dynamic simulations to clarify how the Caulobacter crescentus S-layer assembles on the lipopolysaccharides (LPS) of the cell surface.
中文翻译:
迈向生物规模的结构生物学:细菌LPS抑制了S层。
技术发展正在统一分子和细胞生物学。冯·库格尔根(vonKügelgen)等人最近进行的电子冷冻断层扫描研究。强调了此类研究的光明前景,它们无缝整合了近原子分辨率的蛋白质结构,生物规模的结构,天然质谱和分子动力学模拟,以阐明新月形杆菌S层如何在细胞表面的脂多糖(LPS)上组装。