Synthesis and evaluation of aromatic methoxime derivatives against five postharvest phytopathogenic fungi of fruits. Main structure-activity relationships.,Food Chemistry

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Synthesis and evaluation of aromatic methoxime derivatives against five postharvest phytopathogenic fungi of fruits. Main structure-activity relationships.
Food Chemistry ( IF 8.5 ) Pub Date : 2020-03-27 , DOI: 10.1016/j.foodchem.2020.126701
Iván Cortés ₁ , Melina G di Liberto ₂ , Teodoro S Kaufman ₁ , Marcos G Derita ₃ , Andrea B J Bracca ₁

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The antifungal activity of a library of twenty-four aromatic methoximes was examined against five representative postharvest phytopathogenic fungi. The panel included Penicillium digitatum, Penicillium italicum, Rhizopus stolonifer, Botrytis cinerea and Monilinia fructicola, all of which cause relevant economic losses worldwide as a result of affecting harvested fruits. The minimum inhibitory concentrations and minimum fungicidal concentrations of each compound were defined and the main structure-activity relationships were determined. Although other congeners were more potent, drug likeliness considerations pointed to the methoxime derived from 2,4-dihydroxypropiophenone as the compound with the most suitable profile. The morphology of the colonies of the fungal strains treated with the methoxime was examined microscopically and the compound was also tested in freshly harvested peaches and oranges, exhibiting promising control profiles in both fruits, similar to those of the commercial agents Imazalil and Carbendazim.

中文翻译：

芳香族甲氧肟衍生物对五种水果采后植物病原真菌的合成和评价。主要结构-活动关系。

检查了二十四个芳香族甲肟库对五种代表性的收获后植物病原真菌的抗真菌活性。小组成员包括数位青霉，意大利青霉，根霉，灰葡萄孢和莫尼利尼亚毛果，这些都因影响收获的水果而在世界范围内造成相关的经济损失。确定了每种化合物的最小抑菌浓度和最小杀真菌浓度，并确定了主要的构效关系。尽管其他同类药物更有效，但从药物相似性的角度出发，认为衍生自2,4-二羟基苯乙酮的甲氧肟是最合适的化合物。

更新日期：2020-03-27

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