To date, pharmacokinetics of maslinic (MA) and oleanolic (OA) acids, at normal dietary intakes in humans, have not been evaluated, and data concerning their bioactive effects are scarce. We assessed MA and OA pharmacokinetics after ingestion of olive oils (OOs) with high and low triterpenic acid contents, and specifically the effect of triterpenes on endothelial function. We performed a double-blind, dose-response, randomized, cross-over nutritional intervention in healthy adults, and observed that MA and OA increased in biological fluids in a dose-dependent manner. MA bioavailability was greater than that of OA, and consumption of pentacyclic triterpenes was associated with improved endothelial function. To the best of our knowledge, this is the first time MA pharmacokinetics, and effects on endothelial function in vivo, have been reported in humans.

中文翻译：

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橄榄油中男性和齐墩果酸的药代动力学-对健康成年人内皮功能的影响。一项随机，对照，剂量反应研究。

迄今为止，尚未评估在正常饮食中人类摄入的男性（MA）和齐墩果酸（OA）酸的药代动力学，有关其生物活性作用的数据很少。在摄入具有高和低三萜酸含量的橄榄油（OOs）之后，我们评估了MA和OA的药代动力学，特别是三萜对内皮功能的影响。我们在健康成年人中进行了双盲，剂量反应，随机，交叉营养干预，并观察到生物液中的MA和OA呈剂量依赖性增加。MA的生物利用度大于OA，五环三萜的消耗与内皮功能改善有关。据我们所知，这是首次MA药代动力学及其对体内内皮功能的影响，