Copper catalyzed the [3+3] coupling of the oxime esters with β-CF₃-acrylonitrile toward divergent fluoroalkyl-substituted 2-aminopyridines was described. This redox-neutral coupling conditions with the acrylonitrile affording the trifluoromethylated 2-aminopyridines, respectively, under the reductive conditions, difluoromethylated 2-aminopyridines were obtained. The reactions occurred under mild conditions with high functional-group compatibility and excellent regioselectivity.

中文翻译：

---

通过容易的访问到氟烷基2-氨基吡啶铜催化的[3 + 3]肟酯的联轴器与β-CF ₃丙烯腈

铜催化的[3 + 3]的肟酯与β-CF的连接₃ -丙烯腈朝向发散氟烷基取代的2-氨基吡啶进行了说明。在还原条件下，用丙烯腈分别提供三氟甲基化的2-氨基吡啶的氧化还原-中性偶联条件得到了二氟甲基化的2-氨基吡啶。反应在温和条件下进行，具有高官能团相容性和出色的区域选择性。