Acute myocardial infarction (AMI) is the leading cause of death globally and has thus placed a heavy burden on healthcare. Tanshinone IIA (TSA) is a major active compound, extracted from Salvia miltiorrhiza Bunge, that possesses various pharmacological activities. The aim of the present study was to investigate the role of TSA in AMI and its underlying mechanism of action. Results: We have shown that TSA decreased the apoptosis rate, the amount of LDH, MDA as well as ROS of cardiomyocytes. Meantime, it elevated mitochondrial membrane potential (MMP) which was decreased by H/R treatment. It was also determined that miR-124-5p targets AK003290 directly. TSA up-regulated the expression of AK003290 and its function can be reversed by knock down of AK003290 as well as miR-124-5p overexpression. TSA exerts the protective role against H/R induced apoptosis, oxidative and MMP loss of cardiomyocytes via regulating AK003290 and miR-124-5p signaling.

中文翻译：

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丹参酮IIA通过lncRNA AK003290 / miR-124-5p信号传导减轻缺氧/复氧诱导的心肌细胞损伤

急性心肌梗塞（AMI）是全球范围内的主要死亡原因，因此给医疗保健造成了沉重负担。丹参酮IIA（TSA）是从丹参中提取的一种主要活性化合物，具有多种药理活性。本研究的目的是调查TSA在AMI中的作用及其潜在的作用机制。结果：我们已经表明，TSA降低了心肌细胞的凋亡率，LDH，MDA以及ROS。同时，它增加了线粒体膜电位（MMP），而通过H / R处理却降低了。还确定了miR-124-5p直接靶向AK003290。TSA上调了AK003290的表达，其功能可以通过敲除AK003290以及miR-124-5p过表达来逆转。