Determination and Correlation of the Solubility of Monosodium Fumarate in Different Neat and Binary Solvent Systems,Journal of Chemical & Engineering Data

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Determination and Correlation of the Solubility of Monosodium Fumarate in Different Neat and Binary Solvent Systems
Journal of Chemical & Engineering Data ( IF 2.0 ) Pub Date : 2020-03-27 , DOI: 10.1021/acs.jced.9b01203
Haoyou Liu _{1,

2} , Shen Hu _{1,

2} , Jiaming Han _{1,

2} , Jingxuan Qiu ₁ , Dengjing Yi _{1,

2} , Mengyao An _{2,

3} , Ying Guo _{1,

2} , Haishuang Huang ₁ , Hui He ₁ , Peng Wang _{1,

2}

Affiliation

Monosodium fumarate solubility in 12 monosolvents (water, methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol, 2-propanol, 2-methyl-1-propanol, ethyl acetate, 1,4-dioxane, acetonitrile, and acetone) and four binary solvents (water + methanol, water + ethanol, water + 2-propanol, and water + acetone) was determined by the gravimetric method from 283.15 to 323.15 K. The solubility order in pure solvents was water > methanol > ethyl acetate > 1,4-dioxane > ethanol > 1-propanol > 1-butanol > acetonitrile > 1-pentanol > 2-propanol > acetone > 2-methyl-1-propanol. Also, it was positively related to experimental temperature and solvent composition for all solvent systems. According to the solubility results, the dissolution behavior of monosodium fumarate in pure solvents was mainly affected by the solvent properties including polarity, hydrogen bond acidity (α), hydrogen bond basicity (β), bipolar/polarizability (π*) and Hildebrand solubility parameter (δ_H). The modified Apelblat, Jouyban–Acree, and Apelblat–Jouyban–Acree models were used to correlate the solubility data, and the values calculated by the three thermodynamic models were found to agree well with the experimental data.

中文翻译：

富马酸钠在不同净溶剂和二元溶剂体系中的溶解度的测定和相关性

富马酸一钠在12种单溶剂（水，甲醇，乙醇，1-丙醇，1-丁醇，1-戊醇，2-丙醇，2-甲基-1-丙醇，乙酸乙酯，1,4-二恶烷，乙腈和丙酮中的溶解度）和四种二元溶剂（水+甲醇，水+乙醇，水+ 2-丙醇和水+丙酮）在283.15至323.15 K之间用重量法测定。在纯溶剂中的溶解度顺序是水>甲醇>乙酸乙酯> 1,4-二恶烷>乙醇> 1-丙醇> 1-丁醇>乙腈> 1-戊醇> 2-丙醇>丙酮> 2-甲基-1-丙醇而且，它与所有溶剂体系的实验温度和溶剂组成呈正相关。根据溶解度结果，_H）。修改后的Apelblat，Jouyban-Acree和Apelblat-Jouyban-Acree模型用于关联溶解度数据，并且发现由三个热力学模型计算出的值与实验数据吻合良好。

更新日期：2020-04-24

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