Anti-inflammatory neo-Clerodane Diterpenoids from Ajuga pantantha.,Journal of Natural Products

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Anti-inflammatory neo-Clerodane Diterpenoids from Ajuga pantantha.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-03-27 , DOI: 10.1021/acs.jnatprod.9b00629
Bangjian Dong ₁ , Xueyuan Yang ₁ , Wenpei Liu ₁ , Lijun An ₁ , Xuke Zhang ₁ , Muhetaer Tuerhong ₂ , Qing Du ₃ , Chunyan Wang ₄ , Munira Abudukeremu ₂ , Jing Xu _{1,

4,

5} , Dongho Lee ₆ , Ling Shuai ₁ , Namrita Lall ₇ , Yuanqiang Guo ₁

Affiliation

Eight new neo-clerodane diterpenoids (1-8) were acquired from the aerial parts of Ajuga pantantha. Spectroscopic data analysis permitted the definition of their structures, and experimental and calculated electronic circular dichroism data were used to define their absolute configurations. Compounds 2 and 4-8 were found to have NO inhibitory effects with IC50 values of 20.2, 45.5, 34.0, 27.0, 45.0, and 25.8 μM, respectively. The more potent compounds 2, 6, and 8 were analyzed to establish their anti-inflammatory mechanism, including regulation of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins as well as their binding interactions with the two proteins.

中文翻译：

来自Ajuga pantantha的抗炎新新氯丁烷二萜。

从Ajuga pantantha的地上部分获得了八种新的新环戊烷二萜（1-8）。光谱数据分析允许定义其结构，并使用实验和计算出的电子圆二色性数据定义其绝对构型。发现化合物2和4-8具有NO抑制作用，IC50值分别为20.2、45.5、34.0、27.0、45.0和25.8μM。分析了更有效的化合物2、6和8，以建立其抗炎机制，包括调节诱导型一氧化氮合酶（iNOS）和环加氧酶2（COX-2）蛋白的表达以及它们与三聚体的结合相互作用。这两种蛋白质。

更新日期：2020-03-27

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