Dual Catalytic Platform for Enabling sp3 α C–H Arylation and Alkylation of Benzamides,ACS Catalysis

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Dual Catalytic Platform for Enabling sp3 α C–H Arylation and Alkylation of Benzamides
ACS Catalysis ( IF 11.3 ) Pub Date : 2020-03-27 , DOI: 10.1021/acscatal.0c01318
Alexander W. Rand ₁ , Hongfei Yin ₂ , Liang Xu ₂ , Jessica Giacoboni ₂ , Raul Martin-Montero ₂ , Ciro Romano ₂ , John Montgomery ₁ , Ruben Martin _{2,

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Affiliation

A dual catalytic sp³ α C–H arylation and alkylation of benzamides with organic halides is described. This protocol exhibits an exquisite site selectivity, chemoselectivity, and enantioselectivity pattern, offering a complementary reactivity mode to existing sp³ arylation or alkylations via transition metal catalysis or photoredox events.

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