A sodium N-lauryl amino acids (shortly silk sericin surfactant, SSS) is synthesized with lauryl chloride and sericin amino acids recovered from silk industrial waste. The purpose of this study is to explore whether the sericin surfactant can be used as a potential drug delivery carrier. By controlling the proportion of cationic drugs, cytarabine hydrochloride (CH) and anionic SSS, the aggregation behavior, slow release capability and toxicological effects of catanionic aggregates or vesicles, formed through CH and SSS, have been investigated in detail. Dynamic light scattering (DLS), transmission electron microscopy (TEM), and zeta potential analysis showed that the aggregate solution could form a stable vesicle structure when the mass fraction of CH is less than or equal to 0.3. The drug release results showed that the cumulative release rate of the catanionic aggregation solution with CH mass fraction of 0.2 reached a maximum at 18 h, being approximately 9 times greater than that of pure cytarabine. The CH/SSS aggregates had a significant sustained release effect compared with the control group. At the same time, vesicles formed by SSS and CH have better anti-tumor effects compared with the pure drug group. In summary, sericin surfactant from silk industrial waste has a potential use as a drug delivery carrier.

中文翻译：

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来源于丝蛋白的N-月桂基钠氨基酸可以与阿糖胞苷形成阳离子聚集体，作为新型的抗肿瘤药物递送系统。

用月桂酰氯和从蚕丝工业废料中回收的丝胶蛋白氨基酸合成了N-月桂基氨基酸钠（简称丝胶蛋白表面活性剂，SSS）。这项研究的目的是探讨丝胶蛋白表面活性剂是否可以用作潜在的药物递送载体。通过控制阳离子药物，盐酸阿糖胞苷和阴离子SSS的比例，详细研究了通过CH和SSS形成的阳离子聚集体或囊泡的聚集行为，缓释能力和毒理作用。动态光散射（DLS），透射电子显微镜（TEM）和ζ电势分析表明，当CH的质量分数小于或等于0.3时，聚集体溶液可形成稳定的囊泡结构。药物释放结果表明，CH质量分数为0.2的阳离子聚合溶液的累积释放速率在18 h达到最大值，约为纯阿糖胞苷的9倍。与对照组相比，CH / SSS聚集体具有显着的持续释放作用。同时，由SSS和CH形成的囊泡与纯药物组相比具有更好的抗肿瘤作用。总之，丝绸工业废料中的丝胶蛋白表面活性剂具有潜在的药物输送载体的用途。与纯药物组相比，由SSS和CH形成的囊泡具有更好的抗肿瘤作用。总之，来自丝工业废料的丝胶表面活性剂具有潜在的药物输送载体的用途。与纯药物组相比，由SSS和CH形成的囊泡具有更好的抗肿瘤作用。总之，来自丝工业废料的丝胶表面活性剂具有潜在的药物输送载体的用途。