The axial chirality hidden in vitamin D and its application in cocrystal prediction,CrystEngComm

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The axial chirality hidden in vitamin D and its application in cocrystal prediction
CrystEngComm ( IF 2.6 ) Pub Date : 2020-03-26 , DOI: 10.1039/d0ce00229a
Mengfei Guo _{1,

2,

3,

4} , Zaiyong Zhang _{4,

5,

6,

7,

8} , Zhaoqiang Chen _{4,

5,

6,

7,

8} , Qiaoce Ding _{4,

5,

6,

7,

8} , Liye Lu _{4,

5,

6,

7,

8} , Qi Zhang _{4,

5,

6,

7,

8} , Jian-Rong Wang _{4,

5,

6,

7,

8} , Xuefeng Mei _{4,

5,

6,

7,

8}

Affiliation

The axial chirality of the non-planar conjugated triene in vitamin D₃ was uncovered for the first time. An ECD titration method was used not only for conformational analysis of vitamin D but also for sensitive detection of hydrogen-bonding interaction in solution. It provides a sensitive approach to predict cocrystal formation.

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