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A terbium(iii) luminescent ATCUN-based peptide sensor for selective and reversible detection of copper(ii) in biological media.
Chemical Communications ( IF 4.9 ) Pub Date : 2020-04-30 , DOI: 10.1039/d0cc01007c
Enrico Falcone 1 , Paulina Gonzalez , Lucie Lorusso , Olivier Sénèque , Peter Faller , Laurent Raibaut
Affiliation  

The measurement of exchangeable Cu2+ levels in biological samples is gaining interest in the context of copper-related pathologies. Here, we report a Tb3+ luminescent turn-off sensor for Cu2+ based on the specific and suitable-affinity Xxx-Zzz-His (ATCUN) peptide motif, enabling Cu2+ detection in the presence of a biological fluorescent background.

中文翻译:

iii(iii)发光的基于ATCUN的肽传感器,用于选择性和可逆地检测生物介质中的铜(ii)。

在与铜有关的病理学背景下,生物样品中可交换的Cu2 +水平的测量越来越受到关注。在这里,我们报告了基于特定且合适的亲和力Xxx-Zzz-His(ATCUN)肽基序的Cu2 +的Tb3 +发光关闭传感器,能够在存在生物荧光背景的情况下检测Cu2 +。
更新日期:2020-03-26
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