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Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes.
Cerebral Cortex ( IF 2.9 ) Pub Date : 2020-03-20 , DOI: 10.1093/cercor/bhaa035
Jean Shin 1, 2 , Shaojie Ma 3, 4 , Edith Hofer 5, 6 , Yash Patel 2 , Daniel E Vosberg 2 , Steven Tilley 2 , Gennady V Roshchupkin 7, 8, 9 , André M M Sousa 10 , Xueqiu Jian 11 , Rebecca Gottesman 12 , Thomas H Mosley 13 , Myriam Fornage 11 , Yasaman Saba 14 , Lukas Pirpamer 5 , Reinhold Schmidt 5 , Helena Schmidt 14 , Amaia Carrion-Castillo 15 , Fabrice Crivello 16 , Bernard Mazoyer 16 , Joshua C Bis 17 , Shuo Li 18 , Qiong Yang 18 , Michelle Luciano 19, 20 , Sherif Karama 21 , Lindsay Lewis 21 , Mark E Bastin 19, 22 , Mathew A Harris 22, 23 , Joanna M Wardlaw 19, 24 , Ian E Deary 19, 20 , Markus Scholz 25, 26 , Markus Loeffler 25, 26 , A Veronica Witte 27, 28, 29 , Frauke Beyer 27, 28 , Arno Villringer 27, 28, 29 , Nicola J Armstrong 30 , Karen A Mather 31, 32 , David Ames 33, 34 , Jiyang Jiang 31 , John B Kwok 35, 36 , Peter R Schofield 32, 36 , Anbupalam Thalamuthu 31 , Julian N Trollor 31, 37 , Margaret J Wright 38, 39 , Henry Brodaty 31, 40 , Wei Wen 31 , Perminder S Sachdev 31, 41 , Natalie Terzikhan 9 , Tavia E Evans 7, 9 , Hieab H H H Adams 7, 9 , M Arfan Ikram 7, 9, 42 , Stefan Frenzel 43 , Sandra van der Auwera-Palitschka 43, 44 , Katharina Wittfeld 43, 44 , Robin Bülow 45 , Hans Jörgen Grabe 43, 44 , Christophe Tzourio 46, 47 , Aniket Mishra 46 , Sophie Maingault 48 , Stephanie Debette 46, 47, 49 , Nathan A Gillespie 50 , Carol E Franz 51, 52 , William S Kremen 51, 52, 53 , Linda Ding 54 , Neda Jahanshad 54 , , Nenad Sestan 3, 4 , Zdenka Pausova 1, 55, 56 , Sudha Seshadri 49, 57 , Tomas Paus 2, 58, 59 ,
Affiliation  

We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade—albeit in a very limited manner—to behaviors as complex as the choice of one’s occupation.

中文翻译:


人类大脑皮层的全球和区域发展:分子结构和职业能力。



我们对前两个主成分 (PC) 的全基因组关联研究 (GWAS) (n = 23 784) 进行了荟萃分析,这些主成分将表面积具有共同差异的皮质区域分组在一起。 PC1(全局)捕获了大多数区域的变化,而 PC2(视觉)特定于初级和次级视觉皮层。我们总共鉴定了 18 个 (PC1) 和 17 个 (PC2) 独立基因座,这些基因座在另外 25 746 个个体中得到了复制。全局 PC1 的位点包括先前与颅内容量和/或一般认知功能相关的位点,例如 MAPT 和 IGF2BP1。视觉 PC2 的基因座包括 DAAM1,它是平面细胞极性途径中的关键参与者。然后我们测试了与职业能力的关联,正如预测的那样,发现全局 PC1 与一般学习能力相关,视觉 PC2 与形式感知能力相关。这些结果表明,人类大脑皮层(及其分子结构)的全球和区域发育的个体间差异(尽管以非常有限的方式)级联到像职业选择这样复杂的行为。
更新日期:2020-03-27
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