Analysis of Epidemiological and Clinical Features in Older Patients With Coronavirus Disease 2019 (COVID-19) Outside Wuhan.,Clinical Infectious Diseases

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Analysis of Epidemiological and Clinical Features in Older Patients With Coronavirus Disease 2019 (COVID-19) Outside Wuhan.
Clinical Infectious Diseases ( IF 8.2 ) Pub Date : 2020-03-25 , DOI: 10.1093/cid/ciaa242
Jiangshan Lian ₁ , Xi Jin ₂ , Shaorui Hao ₁ , Huan Cai ₁ , Shanyan Zhang ₁ , Lin Zheng ₁ , Hongyu Jia ₁ , Jianhua Hu ₁ , Jianguo Gao ₂ , Yimin Zhang ₁ , Xiaoli Zhang ₁ , Guodong Yu ₁ , Xiaoyan Wang ₁ , Jueqing Gu ₁ , Chanyuan Ye ₁ , Ciliang Jin ₁ , Yingfeng Lu ₁ , Xia Yu ₁ , Xiaopeng Yu ₁ , Yue Ren ₂ , Yunqing Qiu ₁ , Lanjuan Li ₁ , Jifang Sheng ₁ , Yida Yang ₁

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BACKGROUND The outbreak of COVID-19 has become a big threat to China, with high contagious capacity and varied mortality. This study aimed to investigate the epidemiological and clinical characteristics of older patients with COVID-19 out of Wuhan. METHODS A retrospective study was performed, with collecting data from medical records of confirmed COVID-19 patients in Zhejiang province from Jan 17 to Feb 12, 2020. Epidemiological, clinical and treatment data were analyzed between those older (≥60y) and younger (<60y) patients. RESULTS Total 788 patients with confirmed COVID-19 were selected, where 136 were older patients with corresponding age of 68.28y±7.314y. There was a significantly higher frequency of women in the older patients compared with the younger patients (57.35% vs 46.47%, P=0.021). The presence of coexisting medical condition was significantly higher in older patients compared with younger patients (55.15% vs 21.93%, P<0.001), including the rate of hypertension, diabetes, heart diseases and COPD. Significantly higher rates of severe (older vs younger groups: 16.18% vs 5.98%, P<0.001)/critical (8.82% vs 0.77%, P<0.001) type, shortness of breath (12.50% vs 3.07%, P<0.001) and high temperature of >39.0℃ (13.97% vs 7.21%, P=0.010) were observed in older patients compared with younger patients. Finally, Higher rates of ICU admission (9.56% vs 1.38%, P<0.001) and methylprednisolone application (28.68% vs 9.36%, P<0.001) were also identified in older patients. CONCLUSIONS The specific epidemiological and clinical features of older COVID-19 patients included significantly higher female gender, body temperature, co-existing of basic diseases and rate of severe and critical type.

更新日期：2020-03-27

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