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Lung function in adults and future burden of obstructive lung diseases in a long-term follow-up.
npj Primary Care Respiratory Medicine ( IF 3.1 ) Pub Date : 2020-03-26 , DOI: 10.1038/s41533-020-0169-z Lene Maria Ørts 1 , Bodil Hammer Bech 2 , Torsten Lauritzen 1 , Anders Helles Carlsen 3 , Annelli Sandbæk 1 , Anders Løkke 4
npj Primary Care Respiratory Medicine ( IF 3.1 ) Pub Date : 2020-03-26 , DOI: 10.1038/s41533-020-0169-z Lene Maria Ørts 1 , Bodil Hammer Bech 2 , Torsten Lauritzen 1 , Anders Helles Carlsen 3 , Annelli Sandbæk 1 , Anders Løkke 4
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Spirometry is recommended in symptomatic smokers to identify obstructive lung diseases. However, it is unknown whether there are certain characteristics that can be used to identify the individual risk of developing obstructive lung diseases. The aim of this study was to examine the association between lung function in adults and burden of lung diseases throughout 27 years of follow-up. We performed a cohort study among individuals aged 30-49 years at baseline (1991). Spirometry measurements were divided into three groups: (1) FEV1/FVC < 70, (2) FEV1/FVC: 70-75, (3) FEV1/FVC > 75 (reference). Using negative binominal regression, the burden of lung diseases was measured by contacts to general practice, hospitalisations, redeemed respiratory medicine and socioeconomic parameters between 1991 and 2017. A total of 905 citizens were included; mean age of 40.3 years, 47.5% were males and 51.2% were smokers at baseline. The group with an FEV1/FVC: 70-75 received more respiratory medicine (IRR = 3.37 (95% CI: 2.69-4.23)), had lower income (IRR = 0.96 (95% CI: 0.93-0.98)), and had more contacts to general practice (IRR = 1.14 (95% CI: 1.07-1.21)) and hospitals for lung diseases (IRR = 2.39 (95% CI: 1.96-5.85)) compared to the reference group. We found an association between lung function and the future burden of lung diseases throughout 27 years of follow-up. In particular, adults with an FEV1/FVC: 70-75 need extra attention in the case finding.
中文翻译：
长期随访中成人的肺功能和未来阻塞性肺疾病的负担。
建议有症状的吸烟者进行肺活量测定，以识别阻塞性肺部疾病。然而，尚不清楚是否存在某些特征可用于识别患阻塞性肺病的个体风险。本研究的目的是检查成人肺功能与 27 年随访期间肺部疾病负担之间的关联。我们对基线年龄为 30-49 岁的个体进行了一项队列研究（1991 年）。肺量计测量结果分为三组：(1) FEV1/FVC < 70，(2) FEV1/FVC：70-75，(3) FEV1/FVC > 75（参考）。使用负二项回归，通过 1991 年至 2017 年间与全科诊所的接触、住院、兑换呼吸科药物和社会经济参数来衡量肺部疾病的负担。总共包括 905 名公民；基线时平均年龄为 40.3 岁，其中 47.5% 为男性，51.2% 为吸烟者。 FEV1/FVC：70-75 的组接受了更多的呼吸内科治疗 (IRR = 3.37 (95% CI: 2.69-4.23))，收入较低 (IRR = 0.96 (95% CI: 0.93-0.98))，并且与参考组相比，更多地接触全科医生（IRR = 1.14（95% CI：1.07-1.21））和肺部疾病医院（IRR = 2.39（95% CI：1.96-5.85））。在 27 年的随访中，我们发现肺功能与未来肺部疾病负担之间存在关联。特别是，FEV1/FVC：70-75 的成年人在病例发现时需要特别注意。
更新日期：2020-03-26
中文翻译：
长期随访中成人的肺功能和未来阻塞性肺疾病的负担。
建议有症状的吸烟者进行肺活量测定，以识别阻塞性肺部疾病。然而，尚不清楚是否存在某些特征可用于识别患阻塞性肺病的个体风险。本研究的目的是检查成人肺功能与 27 年随访期间肺部疾病负担之间的关联。我们对基线年龄为 30-49 岁的个体进行了一项队列研究（1991 年）。肺量计测量结果分为三组：(1) FEV1/FVC < 70，(2) FEV1/FVC：70-75，(3) FEV1/FVC > 75（参考）。使用负二项回归，通过 1991 年至 2017 年间与全科诊所的接触、住院、兑换呼吸科药物和社会经济参数来衡量肺部疾病的负担。总共包括 905 名公民；基线时平均年龄为 40.3 岁，其中 47.5% 为男性，51.2% 为吸烟者。 FEV1/FVC：70-75 的组接受了更多的呼吸内科治疗 (IRR = 3.37 (95% CI: 2.69-4.23))，收入较低 (IRR = 0.96 (95% CI: 0.93-0.98))，并且与参考组相比，更多地接触全科医生（IRR = 1.14（95% CI：1.07-1.21））和肺部疾病医院（IRR = 2.39（95% CI：1.96-5.85））。在 27 年的随访中，我们发现肺功能与未来肺部疾病负担之间存在关联。特别是，FEV1/FVC：70-75 的成年人在病例发现时需要特别注意。
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