Nasal continuous positive airway pressure versus noninvasive NAVA in preterm neonates with apnea of prematurity: a pilot study with a novel approach.,Journal of Perinatology

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Nasal continuous positive airway pressure versus noninvasive NAVA in preterm neonates with apnea of prematurity: a pilot study with a novel approach.
Journal of Perinatology ( IF 2.4 ) Pub Date : 2020-03-26 , DOI: 10.1038/s41372-020-0661-x
Kimberly Firestone ₁ , Bassel Al Horany ₂ , Laurence de Leon-Belden ₃ , Howard Stein _{3,

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Affiliation

BACKGROUND Neonates with apnea of prematurity often fail CPAP because it does not provide adequate support during apnea. NAVA provides proportional ventilator support based on electrical activity of the diaphragm. When the NAVA level is 0 cmH20/mcV, the patient receives minimal support above PEEP when breathing and backup ventilation when apneic. This study compares number of clinically significant events on CPAP versus noninvasive NAVA level 0. METHODS Retrospective study of preterm neonates having apnea of prematurity on nasal CPAP. Patients were then placed on NAVA level 0. The number of events on each mode was collected. Statistics were paired t-test. RESULTS Seventeen subjects with gestational age 26.1 ± 1.7 weeks, study age 19.5 ± 12.5 days. Events decreased from 17.9 ± 7.8 on CPAP to 10.2 ± 8.1 events on NAVA level 0 (p = 0.00047). CONCLUSIONS NAVA level 0 reduced the number of clinically significant events compared with CPAP in premature neonates with apnea of prematurity.

中文翻译：

经鼻持续气道正压通气与无创 NAVA 治疗早产儿呼吸暂停的早产儿：一项采用新方法的初步研究。

背景技术患有早产呼吸暂停的新生儿经常无法进行CPAP呼吸机治疗，因为CPAP呼吸机不能在呼吸暂停期间提供足够的支持。 NAVA 根据隔膜的电活动提供比例呼吸机支持。当 NAVA 水平为 0 cmH20/mcV 时，患者在呼吸时获得高于 PEEP 的最小支持，在呼吸暂停时获得备用通气。本研究比较了 CPAP 与无创 NAVA 0 级的临床显着事件的数量。方法对经鼻 CPAP 治疗时出现早产呼吸暂停的早产儿进行回顾性研究。然后将患者置于 NAVA 0 级。收集每种模式的事件数。统计数据采用配对t检验。结果 17 名受试者的胎龄为 26.1 ± 1.7 周，研究年龄为 19.5 ± 12.5 天。事件从 CPAP 时的 17.9 ± 7.8 减少到 NAVA 0 级时的 10.2 ± 8.1 事件 (p = 0.00047)。结论对于患有早产儿呼吸暂停的早产儿，NAVA 0 级与 CPAP 相比减少了临床显着事件的数量。

更新日期：2020-04-24

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