Various probe configurations were modeled. The resulting fluorescence spectra of a human-skin tissue model were analyzed. The Monte Carlo method implemented in the TracePro software package was used to simulate light propagation in the tissue and optical fiber. The endogenous fluorophores riboflavin and protoporphyrin IX served as fluorescence sources in the skin model, had minimally overlapping emission spectra, and provided fluorescence of human skin when excited by laser radiation at 405 nm. The assumption that the fluorescence signal could be selected according to tissue depth using specific parameters of the fiber optic probes was verified. Model spectra using six configurations of fiber optic probes were obtained for the first time with selective sensing of skin auto fluorescence.

中文翻译：

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多层生物组织选择性荧光传感的光纤探针建模

对各种探针配置进行了建模。分析了人类皮肤组织模型的荧光光谱。TracePro软件包中实现的Monte Carlo方法用于模拟光在组织和光纤中的传播。内源性荧光素核黄素和原卟啉IX在皮肤模型中充当荧光源，具有最小的重叠发射光谱，并在405 nm的激光辐射激发下提供人皮肤的荧光。验证了可以使用光纤探针的特定参数根据组织深度选择荧光信号的假设。首次使用六种配置的光纤探头通过选择性感应皮肤自发荧光获得模型光谱。