Use of organophosphorus flame retardants (OPFRs) in consumer materials has led to widespread human exposure. Research is needed to examine the health effects attributable to the general population’s exposure to OPFRs. Using the data from the National Health and Nutrition Examination Surveys (NHANES) (2013–2014), multiple regression analyses were performed to compare the adjusted geometric means (aGMs) of serum sex hormone by quartiles of urinary metabolites of OPFRs, including diphenyl phosphate (DPhP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), bis(2-chloroethyl) phosphate (BCEP) and dibutyl phosphate(DBuP), in children (6–9 years old), adolescents (10–19 years old) and adults(≥ 20 years old), while accounting for potential confounding factors. The aGMs of sex hormone-binding globulin increased by 36% (95% CI 6.1–56.7%) in female children (p = 0.03), 44% (95% CI 16–63%) in female adolescents (p = 0.010), and 22% (95% CI 3.51–37%) in female adults (p = 0.025), from the 1st to 4th quartiles of the levels of DPhP, BDCPP, DBUP, respectively. The aGMs of estradiol (EST) decreased by 64% and 77% from the 1st to 4th quartiles of the DBUP levels in female children (p = 0.015) and female adolescent (p = 0.020), respectively. The aGMs of EST increased by 31% (95% CI 3.8–51%) from the 1st to 4th quartiles of the DBUP levels in female adults (p = 0.031). These findings suggest that exposure to certain OPFRs is associated with the altered sex hormone levels in this sample of US population. More studies are needed to examine the mechanisms responsible for these observations.

在消费品中使用有机磷阻燃剂 (OPFR) 已导致人类广泛接触。需要进行研究以检查可归因于普通人群暴露于 OPFRs 的健康影响。使用来自全国健康和营养检查调查 (NHANES) (2013-2014) 的数据，进行多元回归分析，以通过 OPFR 的尿代谢物（包括磷酸二苯酯）的四分位数来比较血清性激素的调整几何平均值 (aGMs)。 DPhP), bis(1,3-二氯-2-丙基)磷酸酯 (BDCPP)、磷酸双(2-氯乙基)酯 (BCEP) 和磷酸二丁酯 (DBuP)，适用于儿童（6-9 岁）、青少年（10-19 岁） ) 和成人（≥ 20 岁），同时考虑潜在的混杂因素。女性儿童 ( p  = 0.03) 中性激素结合球蛋白的 aGMs 增加了 36% (95% CI 6.1–56.7%)，女性青少年增加了44% (95% CI 16–63%) ( p  = 0.010)，和 22% (95% CI 3.51–37%) 在成年女性 ( p  = 0.025) 中，分别是 DPhP、BDCPP、DBUP 水平的第 1 到第 4 个四分位数。雌二醇 (EST) 的 aGMs 从 DBUP 水平的第 1 到第 4 个四分位数在女性儿童 ( p  = 0.015) 和女性青少年 ( p = 0.020)，分别。从成年女性 DBUP 水平的第 1 到第 4 个四分位数，EST 的 aGM 增加了 31%（95% CI 3.8–51%）（p  = 0.031）。这些发现表明，暴露于某些 OPFRs 与这个美国人口样本中性激素水平的改变有关。需要更多的研究来检查导致这些观察结果的机制。