Over the past decade, it has become apparent that metabolic reprogramming is a key event in tumor progression. The tumor microenvironment (TME) is a source of metabolites for tumor cells. Lipid-filled mature adipocytes are frequently found in proximity to invasive human tumors and release free fatty acids (FFAs) through lipolysis. These FFAs are taken up by tumor cells and used to promote tumor progression by mechanisms that include mitochondrial fatty acid oxidation (FAO). This review discusses recent advances in our understanding of this metabolic symbiosis between adipocytes and cancer cells and underlines the differences in this metabolic crosstalk between the various types of cancer and their localization.

在过去的十年中，很明显，代谢重编程是肿瘤进展中的关键事件。肿瘤微环境（TME）是肿瘤细胞代谢产物的来源。充满脂质的成熟脂肪细胞经常在侵入性人类肿瘤附近发现，并通过脂解作用释放出游离脂肪酸（FFA）。这些FFA被肿瘤细胞吸收，并通过包括线粒体脂肪酸氧化（FAO）在内的机制促进肿瘤进展。这篇综述讨论了我们对脂肪细胞和癌细胞之间这种代谢共生的理解的最新进展，并强调了各种类型的癌症及其定位之间这种代谢串扰的差异。