In this paper, a magnetic and highly porous nanocarrier was synthesized via growing the MIL-100(Fe) on Fe₃O₄@SiO₂ nanoparticles. The effect of several factors on celecoxib adsorption and its release behavior were investigated. The adsorption of celecoxib on Fe₃O₄@SiO₂@MIL-100(Fe) NPs followed the Langmuir isotherm model, indicating the monolayer sorption of the drug molecules on the active sites of the nanocarrier. The adsorption process was completed in only 30 min, followed by the pseudo-second-order and intraparticle adsorption kinetic model. The release study at different pH showed that there is a controlled release at physiological pH (~7.4) while the release becomes burst at acidic pH. The result described by the Higuchi and the Korsmeyer-Peppas release kinetic models for neutral pH (i.e., 7.4) and acidic pH, respectively. The cytotoxicity of the as-synthesized nanocarrier was investigated using MTT assay. The developed nanocarrier showed high biocompatibility with normal NIH-3T3 cells. However, the release in the acidic environment of Hela cancer cells revealed the high potential of the developed nanocarrier for future In-vivo studies.

本文通过在M ₃ O ₄ @SiO ₂纳米颗粒上生长MIL-100（Fe）合成了磁性高多孔的纳米载体。研究了几种因素对塞来昔布吸附及其释放行为的影响。塞来昔布在Fe ₃ O ₄ @SiO ₂上的吸附@ MIL-100（Fe）NPs遵循Langmuir等温模型，表明药物分子在纳米载体活性位点上的单层吸附。吸附过程仅在30分钟内完成，然后是假二级和颗粒内吸附动力学模型。在不同pH值下的释放研究表明，在生理pH值（〜7.4）下有一个受控释放，而在酸性pH值下该释放突然爆发。Higuchi和Korsmeyer-Peppas描述的结果分别释放了中性pH（即7.4）和酸性pH的动力学模型。使用MTT测定法研究了所合成的纳米载体的细胞毒性。已开发的纳米载体显示出与正常NIH-3T3细胞的高度生物相容性。然而，