The magnetic reduction-responsive alginate-based microcapsules (MRAMCs) have been developed successfully with thiolated alginate and oleic acid (OA) modified Fe3O4 nanoparticles (OA-Fe3O4 NPs) via a facile sonochemical method. The obtained MRAMCs could be used as multifunctional carriers for hydrophobic drugs targeted delivery and triggered release due to their merits, such as biocompatibility, non-immunogenicity, magnetic targeting drug delivery and reduction-responsive drug release. The MRAMCs were endowed with magnetic targeting function owing to the encapsulation of the superparamagnetic OA-Fe3O4 NPs, which was confirmed by transmission electron microscope and vibrating sample magnetometer. In addition, the MRAMCs presented excellent reduction-responsive release ability for hydrophobic drugs on account of the disulfide bonds in the wall of microcapsules, which were formed by the cross-linking of sulfhydryl groups on thiolated alginate under ulstrasonication. Meanwhile, confocal laser scanning microscopy measurement indicated that coumarin 6 acted as a hydrophobic model drug could be loaded into MRAMCs easily by dissolving in soybean oil before ultrasonication. Overall, these results demonstrated that MRAMCs would be a promising platform to build controllable drug delivery systems for targeted delivery and triggered release of hydrophobic drugs in biomedical application.

中文翻译：

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用于药物递送的基于磁性还原反应的藻酸盐微胶囊的声化学制备。

磁性还原响应藻酸盐基微囊（MRAMCs）已通过一种简便的声化学方法成功地与硫醇化藻酸盐和油酸（OA）修饰的Fe3O4纳米颗粒（OA-Fe3O4 NPs）一起开发。所获得的MRAMC由于具有生物相容性，非免疫原性，磁性靶向药物递送和还原反应性药物释放等优点，可以用作疏水性药物靶向递送和触发释放的多功能载体。由于超顺磁性OA-Fe 3 O 4 NP的包封，MRAMC具有磁性靶向功能，这通过透射电子显微镜和振动样品磁力计证实。此外，由于微囊壁中的二硫键是在超音速作用下硫醇化藻酸盐上的巯基交联形成的，因此MRAMC对疏水性药物具有出色的还原反应释放能力。同时，共聚焦激光扫描显微镜测量表明，香豆素6作为疏水性模型药物，可以通过在超声处理前溶于大豆油中而容易地装载到MRAMC中。总体而言，这些结果表明，MRAMCs将是一个有前途的平台，可建立可控药物输送系统，以在生物医学应用中靶向输送和引发疏水性药物的释放。共聚焦激光扫描显微镜测量表明，香豆素6作为疏水模型药物，可以通过在超声处理前溶于大豆油中而容易地装载到MRAMC中。总体而言，这些结果表明，MRAMCs将是一个有前途的平台，可建立可控药物输送系统，以在生物医学应用中靶向输送和引发疏水性药物的释放。共聚焦激光扫描显微镜测量表明，香豆素6作为疏水模型药物，可以通过在超声处理前溶于大豆油中而容易地装载到MRAMC中。总体而言，这些结果表明，MRAMCs将是一个有前途的平台，可建立可控药物输送系统，以在生物医学应用中靶向输送和引发疏水性药物的释放。