Natural polymers like polysaccharides, polypeptides and their derivatives are broadly applied in drug delivery due to excellent biocompatibility and biodegradability. In this study, the dissolving tablets, formed with carboxymethylcellulose/poly-l-lysine/tripolyphosphate (CMC/PLL/TPP) complex, were prepared using metformin hydrochloride (MetHCl) as model drug. Confocal laser scanning microscopy observation manifested that FITC-labeled PLL interacted with CMC and formed a uniform interior microstructure. Scanning electron microscope images showed the drug-loaded tablets had well-formed shapes with smooth surfaces. MetHCl embedded interior the microstructures of the tablets and represented in a crystal form. Thermo-gravimetric analysis and differential scanning calorimetry indicated that the drug-loaded tablets had stable thermal properties with less moisture content (3.52%). Fourier transform infrared spectrometer confirmed that the CMC/PLL/TPP complex was fabricated via the electrostatic interactions between -NH3+, -COO- and -[P2O54-]- groups. The drug-loaded tablets had a high drug loading efficiency of 85.76% and drug encapsulation efficiency of 81.47%, and a shorter wetting time of 2.16 min in SSF (pH 6.8) and lower swelling ratio of 233.34%. The drug loaded in the samples could be released completely within 10 min in simulated saliva fluid (SSF pH 6.8), indicating a rapid drug release and dissolving profile in the environment, which could be developed for dissolving tablets.

中文翻译：

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用新型羧甲基纤维素/聚-1-赖氨酸/ TPP复合物开发盐酸二甲双胍溶出片。

天然聚合物（如多糖，多肽及其衍生物）具有出色的生物相容性和生物降解性，因此广泛用于药物输送。在这项研究中，使用盐酸二甲双胍（MetHCl）作为模型药物，制备了由羧甲基纤维素/聚-1-赖氨酸/三聚磷酸盐（CMC / PLL / TPP）复合物形成的溶解片剂。共聚焦激光扫描显微镜观察表明，FITC标记的PLL与CMC相互作用并形成均匀的内部微观结构。扫描电子显微镜图像显示载药的片剂具有良好的形状，具有光滑的表面。MetHCl嵌入片剂的微结构内部，并以晶体形式表示。热重分析和差示扫描量热法表明，载药片剂具有稳定的热性能，且水分含量较低（3.52％）。傅里叶变换红外光谱仪证实，CMC / PLL / TPP络合物是通过-NH3 +，-COO-和-[P2O54-]-基团之间的静电相互作用制备的。载药片剂的载药率高，达85.76％，包封率达81.47％，在SSF（pH 6.8）中的润湿时间较短，为2.16min，溶胀率较低，为233.34％。样品中加载的药物可以在10分钟内在模拟唾液（SSF pH 6.8）中完全释放，这表明药物在环境中的释放和溶解特性迅速，可以开发用于溶解片剂的药物。傅里叶变换红外光谱仪证实，CMC / PLL / TPP络合物是通过-NH3 +，-COO-和-[P2O54-]-基团之间的静电相互作用制备的。载药片剂的载药率高，达85.76％，包封率达81.47％，在SSF（pH 6.8）中的润湿时间较短，为2.16min，溶胀率较低，为233.34％。样品中加载的药物可以在10分钟内在模拟唾液（SSF pH 6.8）中完全释放，这表明药物在环境中的释放和溶解特性迅速，可以开发用于溶解片剂的药物。傅里叶变换红外光谱仪证实，CMC / PLL / TPP络合物是通过-NH3 +，-COO-和-[P2O54-]-基团之间的静电相互作用制备的。载药片剂的载药率高，达85.76％，包封率达81.47％，在SSF（pH 6.8）中的润湿时间较短，为2.16min，溶胀率较低，为233.34％。样品中加载的药物可以在10分钟内在模拟唾液（SSF pH 6.8）中完全释放，这表明药物在环境中的释放和溶解特性迅速，可以开发用于溶解片剂的药物。在SSF（pH 6.8）中润湿时间缩短了2.16分钟，溶胀率降低了233.34％。样品中加载的药物可以在10分钟内在模拟唾液（SSF pH 6.8）中完全释放，这表明药物在环境中的释放和溶解特性迅速，可以开发用于溶解片剂的药物。在SSF（pH 6.8）中润湿时间缩短了2.16分钟，溶胀率降低了233.34％。样品中加载的药物可以在10分钟内在模拟唾液（SSF pH 6.8）中完全释放，这表明药物在环境中的释放和溶解特性迅速，可以开发用于溶解片剂的药物。