当前位置：
X-MOL 学术
›
Int. J. Biol. Macromol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Linum usitatissimum seed mucilage-alginate mucoadhesive microspheres of metformin HCl: Fabrication, characterization and evaluation.
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2020-03-26 , DOI: 10.1016/j.ijbiomac.2020.03.181 Shazia Akram Ghumman 1 , Sobia Noreen 2 , Sidra Tul Muntaha 1
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2020-03-26 , DOI: 10.1016/j.ijbiomac.2020.03.181 Shazia Akram Ghumman 1 , Sobia Noreen 2 , Sidra Tul Muntaha 1
Affiliation
|
This study investigates the fabrication, characterization and optimization of Linum usitatissimum mucilage (LSM) with sodium alginate mucoadhesive microspheres loaded metformin HCl, a sustained release dosage form prepared by ionic gelation technique. The effect of changing the polymer ratio with drug was studied for drug encapsulation efficiency and in vitro drug release for 12 h. Drug entrapment efficiency of all formulations was in the range of 77.93 ± 3.67 to 92.25 ± 4.08% with sustained release of 80 ± 0.12% to 88 ± 0.33% for 12 h. It followed Korsmeyers Peppas model (R2 = 0.9786-0.9964) with super case II transport mechanism. Average microsphere size of all formulations was within the range of 817-911 μm. SEM, FTIR were also characterized and swelling behavior of microspheres was affected by pH of buffer medium. These microspheres also showed good mucoadhesivity in wash off test. The optimized LSM-alginate mucoadhesive microspheres containing metformin HCl demonstrated significant hypoglycemic effect in alloxan-induced diabetic rats for prolonged period of time.
中文翻译：
盐酸二甲双胍的亚麻亚麻仁种子-藻酸盐粘膜粘附微球：制备，表征和评价。
本研究研究了用海藻酸钠粘膜粘附微球负载二甲双胍HCl（一种通过离子凝胶技术制备的缓释剂型）制备亚麻亚麻酸（LSM）的工艺，表征和优化。研究了用药物改变聚合物比例的效果，研究了药物的包封效率和12h的体外药物释放。所有制剂的药物截留效率在77.93±3.67至92.25±4.08％的范围内，持续释放80±0.12％至88±0.33％，持续12小时。它遵循具有超级案例II传输机制的Korsmeyers Peppas模型（R2 = 0.9786-0.9964）。所有制剂的平均微球尺寸在817-911μm的范围内。还表征了SEM，FTIR，并且缓冲液的pH影响了微球的溶胀行为。这些微球在冲洗试验中也显示出良好的粘膜粘附性。优化的含盐酸二甲双胍的LSM-藻酸盐粘膜粘附微球在四氧嘧啶诱导的糖尿病大鼠中长时间显示出明显的降血糖作用。
更新日期：2020-03-27
中文翻译：
盐酸二甲双胍的亚麻亚麻仁种子-藻酸盐粘膜粘附微球：制备，表征和评价。
本研究研究了用海藻酸钠粘膜粘附微球负载二甲双胍HCl（一种通过离子凝胶技术制备的缓释剂型）制备亚麻亚麻酸（LSM）的工艺，表征和优化。研究了用药物改变聚合物比例的效果，研究了药物的包封效率和12h的体外药物释放。所有制剂的药物截留效率在77.93±3.67至92.25±4.08％的范围内，持续释放80±0.12％至88±0.33％，持续12小时。它遵循具有超级案例II传输机制的Korsmeyers Peppas模型（R2 = 0.9786-0.9964）。所有制剂的平均微球尺寸在817-911μm的范围内。还表征了SEM，FTIR，并且缓冲液的pH影响了微球的溶胀行为。这些微球在冲洗试验中也显示出良好的粘膜粘附性。优化的含盐酸二甲双胍的LSM-藻酸盐粘膜粘附微球在四氧嘧啶诱导的糖尿病大鼠中长时间显示出明显的降血糖作用。
京公网安备 11010802027423号