Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common causes of hospital infection. Here, we showed that hyaluronic acid modified organic metal framework material ZIF-8 could be a Trojan horse of vancomycin (Van) for effective treatment of MRSA infections. The Van-loaded nanoparticles were readily up-taken by macrophages via a CD44-mediated process and collapsed in the acidic condition of endosome/lysosome, as a consequence, it could eradicate MRSA with high efficiency in macrophages. This drug delivery system with negligible toxicity could resolve MRSA infections in a well-established mouse pneumonia model.

中文翻译：

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透明质酸涂层的ZIF-8用于治疗由耐甲氧西林的金黄色葡萄球菌引起的肺炎。

耐甲氧西林金黄色葡萄球菌（MRSA）是医院感染的最常见原因之一。在这里，我们表明透明质酸修饰的有机金属骨架材料ZIF-8可能是万古霉素（Van）的特洛伊木马，可有效治疗MRSA感染。载有Van的纳米颗粒很容易通过CD44介导的过程被巨噬细胞摄取，并在内体/溶酶体的酸性条件下坍塌，因此，它可以在巨噬细胞中高效清除MRSA。这种毒性可忽略不计的药物递送系统可以在公认的小鼠肺炎模型中解决MRSA感染。