Gum Arabic (GA) is a biocompatible polymer with the necessary requirements for a wound dressing. However, electrospinning of GA is a bottleneck due to its physico-chemical properties. The aim of this study was to fabricate an antimicrobial nanofibers mat from GA with suitable porosity, water absorption, water vapor permeability and mechanical strength. For this purpose, the composition of polycaprolacton (PCL)-coated GA-polyvinyl alcohol (PVA) nanofibers mat was optimized based on the possible highest porosity, water absorption and water vapor permeability, and then silver nanoparticles (AgNPs) loaded nanofibers mat was prepared based on this composition. The synthesis of AgNPs was supported by UV-vis and ICP analyses. The structure of mat and its constituents were characterized by FE-SEM, XRD and FTIR. The results showed that the average diameter of nanofibers was in the range of 150 to 250 nm with the porosity, water absorption and water vapor permeability of 37.34%, 547.30% and 2235.50 g/m2.day, respectively. The antimicrobial activity of mat against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans was proved. Moreover, the cytotoxicity of mat showed the good biocompatibility for the mouse embryonic fibroblast cells. This study introduced PCL-coated GA-PVA-AgNPs as an effective antimicrobial mat alternative for commercial wound dressing.

中文翻译：

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基于载有银纳米颗粒的阿拉伯胶纳米纤维的抗菌伤口敷料的合成与表征。

阿拉伯胶（GA）是一种生物相容性聚合物，具有伤口敷料的必要要求。然而，由于其物理化学性质，GA的电纺丝成为瓶颈。这项研究的目的是由GA制备具有适当孔隙率，吸水率，水蒸气渗透性和机械强度的抗菌纳米纤维毡。为此，基于可能的最高孔隙率，吸水率和水蒸气渗透性，优化了聚己内酰胺（PCL）涂层的GA-聚乙烯醇（PVA）纳米纤维垫的组成，然后制备了载有银纳米颗粒（AgNPs）的纳米纤维垫。基于此组成。AgNPs的合成得到UV-vis和ICP分析的支持。用FE-SEM，XRD和FTIR对毡的结构及其成分进行了表征。结果表明，纳米纤维的平均直径为150-250 nm，孔隙率，吸水率和水蒸气渗透率分别为37.34％，547.30％和2235.50 g / m2.day。证明了该垫对金黄色葡萄球菌，大肠杆菌，铜绿假单胞菌和白色念珠菌的抗菌活性。此外，垫的细胞毒性对小鼠胚胎成纤维细胞显示出良好的生物相容性。这项研究介绍了PCL涂层GA-PVA-AgNPs作为商业伤口敷料的有效抗菌垫替代品。证明了铜绿假单胞菌和白色念珠菌。此外，垫的细胞毒性对小鼠胚胎成纤维细胞显示出良好的生物相容性。这项研究介绍了PCL涂层GA-PVA-AgNPs作为商业伤口敷料的有效抗菌垫替代品。证明了铜绿假单胞菌和白色念珠菌。此外，垫的细胞毒性对小鼠胚胎成纤维细胞显示出良好的生物相容性。这项研究介绍了PCL涂层GA-PVA-AgNPs作为商业伤口敷料的有效抗菌垫替代品。