Social jetlag and sleep deprivation are associated with altered activity in the reward-related brain areas: an exploratory resting-state fMRI study.,Sleep Medicine

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Social jetlag and sleep deprivation are associated with altered activity in the reward-related brain areas: an exploratory resting-state fMRI study.
Sleep Medicine ( IF 3.8 ) Pub Date : 2020-03-26 , DOI: 10.1016/j.sleep.2020.03.018
Ruben Emanuel Nechifor ₁ , Dana Ciobanu ₂ , Camelia Larisa Vonica ₂ , Cristian Popita ₃ , Gabriela Roman ₄ , Cornelia Bala ₄ , Andreia Mocan ₅ , Georgeta Inceu ₂ , Anca Craciun ₂ , Adriana Rusu ₂

Affiliation

Objective

The aim of this research was to assess the effect of social jetlag (SJL) and its interaction with partial sleep deprivation on resting-state brain activity using the fractional amplitude of low-frequency fluctuation (fALFF) during free-living conditions.

Methods

A total of 28 normal weight healthy subjects were enrolled in four study groups (with SJL [with sleep deprivation and without sleep deprivation] and without SJL [with sleep deprivation and without sleep deprivation]), matched 1:1:1:1 for age, gender, and body mass index (BMI). Resting-state functional magnetic resonance imaging (fMRI) scans were collected with SIEMENS 3T scanner while subjects were in a fasting state.

Results

Participants with SJL had significantly higher fALFF values in right lingual gyrus and right putamen and significantly lower fALFF values in left and right inferior parietal lobe in comparison with participants without SJL and without sleep deprivation. Subjects with sleep deprivation had significantly higher fALFF in the thalamus and left superior frontal gyrus. In those with both SJL and sleep deprivation, we observed higher fALFF values in right Brodmann Area (BA)18 and lower values in left and right parietal inferior lobe. Subjects with SJL alone had significantly lower fALFF values in left frontal mid gyrus (BA6) than those with sleep deprivation alone.

Conclusions

SJL was associated with altered resting-state brain activity in regions that have been shown to be involved in hedonic feeding. The effect of SJL was independent of effects induced by short sleep duration. These alterations might represent the substrate for the increased risk of obesity observed in those with SJL.

中文翻译：

社交时差和睡眠剥夺与奖赏相关的大脑区域活动的改变有关：一项探索性静止状态功能磁共振成像研究。

目的

这项研究的目的是使用自由生活条件下的低频波动幅度（fALFF）评估社交时差（SJL）及其与部分睡眠剥夺对静息状态大脑活动的相互作用。

方法

总共28名体重正常的健康受试者参加了四个研究组（患有SJL [有睡眠剥夺和无睡眠剥夺]和没有SJL [有睡眠剥夺和无睡眠剥夺]），年龄匹配1：1：1：1 ，性别和体重指数（BMI）。当受试者处于禁食状态时，使用SIEMENS 3T扫描仪收集静止状态功能磁共振成像（fMRI）扫描。

结果

与没有SJL和没有睡眠剥夺的参与者相比，患有SJL的参与者在右舌回和右壳核中的fALFF值显着较高，而在左右下顶叶的fALFF值则显着较低。睡眠剥夺的受试者在丘脑和左上额额回中的fALFF明显较高。在患有SJL和睡眠剥夺的患者中，我们观察到右Brodmann Area（BA）18的fALFF值较高，而左，右顶壁下叶的值较低。单独患有SJL的受试者的左额中回（BA6）的fALFF值显着低于仅有睡眠剥夺的受试者。