Immune mediated inflammatory diseases (IMIDs) have similarities in pathophysiology and treatment. Not much is known, however, about health-related quality of life (HR-QoL) in IMIDs. We assessed and compared HR-QoL, using the validated EuroQoL 5-dimensions 5-levels questionnaire, in an observational cohort comprising 530 patients (67.5% female, mean age 49 years (95% CI 35.9-50.9), mean disease duration 31.0 months (95% CI 27.2-34.8)), with the following IMIDs: connective tissue diseases (32.6%), uveitis (20.8%), inflammatory arthritis (17.7%), psoriasis (15.5%), vasculitis (6.2%), primary antiphospholipid syndrome (4.2%), and autoinflammatory diseases (2.8%). Patients used either no anti-inflammatory therapy (31.5%), monotherapy (28.7%), or a combination of anti-inflammatory drugs (39.8%). The mean HR-QoL utility score was 0.75 (95% CI 0.72-0.78). Multinominal logistic regression analysis showed a statistically significant association between a very low HR-QoL (utility score (<0.70)) and female sex, rheumatological IMID or psoriasis, smoking or having smoked in the past, and current biological disease modifying anti-rheumatic drugs use.

中文翻译：

---

免疫介导的炎症性疾病患者与健康相关的生活质量：一项跨领域，多学科的研究。

免疫介导的炎性疾病（IMID）在病理生理学和治疗上有相似之处。但是，关于IMID中与健康有关的生活质量（HR-QoL）知之甚少。我们在包括530名患者（67.5％的女性，平均年龄49岁（95％的CI 35.9-50.9），平均病程31.0个月）的观察性队列中，使用经过验证的EuroQoL 5维5级问卷对HR-QoL进行了评估和比较。 （95％CI 27.2-34.8）），具有以下IMID：结缔组织疾病（32.6％），葡萄膜炎（20.8％），炎性关节炎（17.7％），牛皮癣（15.5％），血管炎（6.2％），原发性抗磷脂综合征（4.2％）和自身炎症性疾病（2.8％）。患者既不使用抗炎治疗（31.5％），也不使用单一疗法（28.7％）或联合使用抗炎药（39.8％）。平均HR-QoL效用得分为0.75（95％CI为0.72-0.78）。