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Polyurethane nanocomposite impregnated with chitosan-modified graphene oxide as a potential antibacterial wound dressing.
Biomaterials Advances ( IF 5.5 ) Pub Date : 2020-03-26 , DOI: 10.1016/j.msec.2020.110899
Seyed Ahmad Ayati Najafabadi 1 , Abbas Mohammadi 2 , Anousheh Zargar Kharazi 1
Affiliation  

In this study, a polyurethane nanocomposite film (PU/CS-GO) was synthesized by incorporating chitosan-modified GO nanosheets (CS-GO) into PU matrices. The successful synthesis of unmodified GO and CS-GO nanosheets was confirmed by FTIR, XRD, Raman, SEM, EDS, and TGA analyses. In comparison with polyurethane nanocomposite containing unmodified graphene oxide (PU/GO), the effect of the modification of GO with chitosan on different properties such as morphological, thermal, thermo-mechanical, wettability, antibacterial, and biocompatibility properties was evaluated by various analyses including XRD, FE-SEM, TGA, DMTA, contact angle, antibacterial studies, and MTT assay. FE-SEM images exhibited better dispersion of CS-GO nanosheets within polyurethane matrices compared to GO nanosheets. According to DMTA results, PU/CS-GO showed a higher glass transition temperature (Tg) and storage modulus values than PU/GO sample. Based on antibacterial and MTT assays, in comparison with PU/GO, the PU/CS-GO nanocomposite demonstrated better biocompatibility and also antibacterial activity against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria. Based on results, the PU/CS-GO nanocomposite can be suggested as a promising material for antibacterial wound dressing.



中文翻译:

壳聚糖改性的氧化石墨烯浸渍的聚氨酯纳米复合材料作为潜在的抗菌伤口敷料。

在这项研究中,通过将壳聚糖改性的GO纳米片(CS-GO)掺入PU基质中,合成了聚氨酯纳米复合膜(PU / CS-GO)。FTIR,XRD,拉曼,SEM,EDS和TGA分析证实了未修饰的GO和CS-GO纳米片的成功合成。与含有未改性氧化石墨烯(PU / GO)的聚氨酯纳米复合材料相比,用壳聚糖改性GO对不同性质如形态,热,热机械,润湿性,抗菌和生物相容性的影响,包括XRD,FE-SEM,TGA,DMTA,接触角,抗菌研究和MTT分析。与GO纳米片相比,FE-SEM图像显示CS-GO纳米片在聚氨酯基质中的分散性更好。根据DMTA结果,与PU / GO样品相比,PU / CS-GO显示出更高的玻璃化转变温度(Tg)和储能模量值。基于抗菌和MTT分析,与PU / GO相比,PU / CS-GO纳米复合材料表现出更好的生物相容性以及对革兰氏阳性的抗菌活性金黄色葡萄球菌和革兰氏阴性大肠杆菌。基于结果,PU / CS-GO纳米复合材料可被建议用作抗菌伤口敷料的有前途的材料。

更新日期:2020-03-26
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