The innate lymphoid cell (ILC) family consists of natural killer (NK) cells, helper-like lymphoid cells (ILC1s, ILC2s, and ILC3s), and lymphoid tissue inducer (LTi) cells. Helper-like ILCs are considered the innate counterpart of T-helper cells because of similarities in their cytokine output and expression of key transcription factors. ILCs provide and regulate innate immune functions before the development of adaptive immunity. They are involved in host defense against pathogens, inflammation, tissue repair, and metabolic homeostasis. However, they can also be involved in inflammatory disorders and carcinogenesis. In this review, we summarize the latest research on ILC development and plasticity in humans and mice, focusing on the pathogenic role of helper-like ILCs in inflammatory disorders, such as asthma, Crohn's disease (CD), and rheumatoid arthritis (RA).

中文翻译：

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人类和小鼠的辅助性先天淋巴样细胞。

先天性淋巴样细胞（ILC）家族由自然杀伤（NK）细胞，辅助性样淋巴样细胞（ILC1，ILC2和ILC3）和淋巴组织诱导剂（LTi）细胞组成。像辅助细胞一样的ILC被认为是T辅助细胞的先天对应物，因为它们的细胞因子输出和关键转录因子的表达相似。ILC在适应性免疫发展之前提供并调节先天免疫功能。它们参与宿主对抗病原体，炎症，组织修复和代谢稳态的防御。但是，它们也可能参与炎症性疾病和致癌作用。在这篇综述中，我们总结了有关人类和小鼠中ILC发育和可塑性的最新研究，重点是在炎症性疾病（如哮喘，克罗恩病（CD），