The traditional view of protein aggregation as being strictly disease-related has been challenged by many examples of cellular aggregates that regulate beneficial biological functions. When coupled with the emerging view that many regulatory proteins undergo phase separation to form dynamic cellular compartments, it has become clear that supramolecular assembly plays wide-ranging and critical roles in cellular regulation. This presents opportunities to develop new tools to probe and illuminate this biology, and to harness the unique properties of these self-assembling systems for synthetic biology for the purposeful manipulation of biological function.

中文翻译：

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天然和合成生物学中的蛋白质组装系统。

蛋白质聚集与疾病严格相关的传统观点已经受到许多调节有益生物学功能的细胞聚集的例子的挑战。当与新出现的观点相结合时，即许多调节蛋白会经历相分离以形成动态的细胞区室，这一点已经很清楚，超分子组装在细胞调节中起着广泛而关键的作用。这提供了开发新工具的机会，以探测和阐明该生物学，并利用这些自组装系统的独特特性来进行合成生物学，从而有目的地操纵生物学功能。