The Relationship Between White Matter Microstructure and General Cognitive Ability in Patients With Schizophrenia and Healthy Participants in the ENIGMA Consortium.,American Journal of Psychiatry

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The Relationship Between White Matter Microstructure and General Cognitive Ability in Patients With Schizophrenia and Healthy Participants in the ENIGMA Consortium.
American Journal of Psychiatry ( IF 15.1 ) Pub Date : 2020-03-26 , DOI: 10.1176/appi.ajp.2019.19030225
Laurena Holleran ₁ , Sinead Kelly ₁ , Clara Alloza ₁ , Ingrid Agartz ₁ , Ole A Andreassen ₁ , Celso Arango ₁ , Nerisa Banaj ₁ , Vince Calhoun ₁ , Dara Cannon ₁ , Vaughan Carr ₁ , Aiden Corvin ₁ , David C Glahn ₁ , Ruben Gur ₁ , Elliot Hong ₁ , Cyril Hoschl ₁ , Fleur M Howells ₁ , Anthony James ₁ , Joost Janssen ₁ , Peter Kochunov ₁ , Stephen M Lawrie ₁ , Jingyu Liu ₁ , Covadonga Martinez ₁ , Colm McDonald ₁ , Derek Morris ₁ , David Mothersill ₁ , Christos Pantelis ₁ , Fabrizio Piras ₁ , Steven Potkin ₁ , Paul E Rasser ₁ , David Roalf ₁ , Laura Rowland ₁ , Theodore Satterthwaite ₁ , Ulrich Schall ₁ , Gianfranco Spalletta ₁ , Filip Spaniel ₁ , Dan J Stein ₁ , Anne Uhlmann ₁ , Aristotle Voineskos ₁ , Andrew Zalesky ₁ , Theo G M van Erp ₁ , Jessica A Turner ₁ , Ian J Deary ₁ , Paul M Thompson ₁ , Neda Jahanshad ₁ , Gary Donohoe ₁

Affiliation

School of Psychology, Centre for Neuroimaging and Cognitive Genomics, National Centre for Biomedical Engineering Science and Galway Neuroscience Centre, National University of Ireland Galway, Galway (Holleran, Cannon, McDonald, Morris, Mothersill, Donohoe); Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey (Kelly, Thompson, Jahanshad); Department of Psychiatry, University of Edinburgh, Edinburgh (Alloza, Lawrie); Department of Child and Adolescent Psychiatry, Instituto de Investigación Sanitaria Gregorio Marañón, IiSGM, Hospital General Universitario Gregorio Marañón, School of Medicine, CIBERSAM, Universidad Complutense, Madrid (Alloza, Arango, Janssen, Martinez); NORMENT, K.G. Jebsen Center for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo (Agartz); Department of Psychiatry, Ullevål University Hospital and Institute of Psychiatry, University of Oslo, Oslo (Andreassen); Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome (Banaj, Piras, Spalletta); Mind Research Network and Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque (Calhoun); Neuroscience Research Australia and School of Psychiatry, University of New South Wales, Sydney (Carr); Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin (Corvin); Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital and Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (Glahn); Department of Psychiatry, University of Pennsylvania, Philadelphia (Gur, Roalf, Satterthwaite); Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (Hong, Kochunov, Rowland); National Institute of Mental Health, Klecany, Czech Republic (Hoschl, Spaniel); Department of Psychiatry and Mental Health (Howells, Stein, Uhlmann) and Neuroscience Institute (Howells, Stein), University of Cape Town, Cape Town, South Africa; Highfield Unit, Warneford Hospital, Oxford, U.K. (James); Mind Research Network, Lovelace Biomedical and Environmental Research Institute, Albuquerque, N.Mex. (Liu); Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Australia (Pantelis, Zalesky); Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine (Potkin); Priority Centre for Brain and Mental Health Research (Schall, Rasser) and Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, Australia (Rasser); Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (Spalletta); Kimel Family Translational Imaging-Genetics Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto (Voineskos); Department of Biomedical Engineering and Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia (Zalesky); Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, and Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine (van Erp); Department of Psychology, Georgia State University, Atlanta (Turner); and Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh (Deary).

Objective:

Schizophrenia has recently been associated with widespread white matter microstructural abnormalities, but the functional effects of these abnormalities remain unclear. Widespread heterogeneity of results from studies published to date preclude any definitive characterization of the relationship between white matter and cognitive performance in schizophrenia. Given the relevance of deficits in cognitive function to predicting social and functional outcomes in schizophrenia, the authors carried out a meta-analysis of available data through the ENIGMA Consortium, using a common analysis pipeline, to elucidate the relationship between white matter microstructure and a measure of general cognitive performance, IQ, in patients with schizophrenia and healthy participants.

Methods:

The meta-analysis included 760 patients with schizophrenia and 957 healthy participants from 11 participating ENIGMA Consortium sites. For each site, principal component analysis was used to calculate both a global fractional anisotropy component (gFA) and a fractional anisotropy component for six long association tracts (LA-gFA) previously associated with cognition.

Results:

Meta-analyses of regression results indicated that gFA accounted for a significant amount of variation in cognition in the full sample (effect size [Hedges’ g]=0.27, CI=0.17–0.36), with similar effects sizes observed for both the patient (effect size=0.20, CI=0.05–0.35) and healthy participant groups (effect size=0.32, CI=0.18–0.45). Comparable patterns of association were also observed between LA-gFA and cognition for the full sample (effect size=0.28, CI=0.18–0.37), the patient group (effect size=0.23, CI=0.09–0.38), and the healthy participant group (effect size=0.31, CI=0.18–0.44).

Conclusions:

This study provides robust evidence that cognitive ability is associated with global structural connectivity, with higher fractional anisotropy associated with higher IQ. This association was independent of diagnosis; while schizophrenia patients tended to have lower fractional anisotropy and lower IQ than healthy participants, the comparable size of effect in each group suggested a more general, rather than disease-specific, pattern of association.

中文翻译：

ENIGMA 联盟中精神分裂症患者和健康参与者的白质微结构与一般认知能力之间的关系。

客观的：

精神分裂症最近与广泛的白质微结构异常有关，但这些异常的功能影响仍不清楚。迄今为止发表的研究结果的广泛异质性排除了对精神分裂症白质与认知表现之间关系的任何明确表征。鉴于认知功能缺陷与预测精神分裂症的社会和功能结果的相关性，作者通过 ENIGMA 联盟使用通用分析管道对可用数据进行了荟萃分析，以阐明白质微观结构与测量之间的关系精神分裂症患者和健康参与者的一般认知表现，智商。

方法：

荟萃分析包括来自 11 个参与 ENIGMA 联盟站点的 760 名精神分裂症患者和 957 名健康参与者。对于每个站点，主成分分析用于计算先前与认知相关的六个长关联束 (LA-gFA) 的全局分数各向异性分量 (gFA) 和分数各向异性分量。

结果：

回归结果的荟萃分析表明，gFA 占整个样本中认知的显着变化（效应大小 [Hedges' g] = 0.27，CI = 0.17-0.36），对于两个患者都观察到相似的效应大小（影响大小=0.20，CI=0.05-0.35）和健康参与者组（影响大小=0.32，CI=0.18-0.45）。在 LA-gFA 和认知之间也观察到可比较的关联模式，对于完整样本（效应大小 = 0.28，CI = 0.18-0.37）、患者组（效应大小 = 0.23，CI = 0.09-0.38）和健康参与者组（效应大小=0.31，CI=0.18–0.44）。