当前位置：
X-MOL 学术
›
Org. Lett.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Total Syntheses of Fimsbactin A and B and Their Stereoisomers to Probe the Stereoselectivity of the Fimsbactin Uptake Machinery in Acinetobacter baumannii.
Organic Letters ( IF 4.9 ) Pub Date : 2020-03-26 , DOI: 10.1021/acs.orglett.0c00790 Soojeung Kim 1 , Haeun Lee 1 , Woon Young Song 1 , Hak Joong Kim 1, 2
Organic Letters ( IF 4.9 ) Pub Date : 2020-03-26 , DOI: 10.1021/acs.orglett.0c00790 Soojeung Kim 1 , Haeun Lee 1 , Woon Young Song 1 , Hak Joong Kim 1, 2
Affiliation
|
The stereoselective synthesis of fimsbactin A, a siderophore of the human pathogen Acinetobacter baumannii, was established. Based on this synthetic route, various fimsbactin stereoisomeric analogues were generated and tested for their iron delivery activity for A. baumannii. This investigation revealed that the fimsbactin uptake machinery in this bacterium was indeed highly stereoselective in substrate recognition.
中文翻译：
Fimsbactin A和B及其立体异构体的总合成，以探讨鲍曼不动杆菌中Fimsbactin摄取机制的立体选择性。
建立了人类病原体鲍曼不动杆菌铁载体fimsbactin A的立体选择性合成。基于该合成途径，产生了多种纤维芽孢素立体异构体类似物，并测试了它们对鲍曼不动杆菌的铁递送活性。这项研究表明，该细菌中的丝菌素摄取机制确实在底物识别方面具有高度立体选择性。
更新日期：2020-03-27
中文翻译：
Fimsbactin A和B及其立体异构体的总合成，以探讨鲍曼不动杆菌中Fimsbactin摄取机制的立体选择性。
建立了人类病原体鲍曼不动杆菌铁载体fimsbactin A的立体选择性合成。基于该合成途径，产生了多种纤维芽孢素立体异构体类似物，并测试了它们对鲍曼不动杆菌的铁递送活性。这项研究表明，该细菌中的丝菌素摄取机制确实在底物识别方面具有高度立体选择性。
京公网安备 11010802027423号