Malignant ascites is one of the major clinical features of ovarian cancer, which serves as a carrier for the peritoneal dissemination of tumor cells and predicts a poor prognosis in patients. In the microenvironment of ovarian cancer ascites, antitumor immunity is suppressed, which enables the tumor cells to escape from immune surveillance. The metabolic factors, including hypoxia, nutrient deprivation and accumulation of metabolic products, contribute to the immunosuppressive status of malignant ascites. The malignant ascites and ovarian solid tumors exhibit differential metabolic profiles. In this review, we have summarized the most recent findings on the interaction between immune cells and metabolic factors in the ovarian cancer ascites. The effects of metabolic factors on the antitumor functions of T‐cells in the malignant ascites were analyzed. Finally, we have discussed the potential directions for future research in this field.

中文翻译：

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代谢因子有助于抑制卵巢癌腹水中的T细胞。

恶性腹水是卵巢癌的主要临床特征之一，其可作为腹膜扩散肿瘤细胞的载体，并预示患者的预后不良。在卵巢癌腹水的微环境中，抗肿瘤免疫力受到抑制，这使得肿瘤细胞可以逃避免疫监视。包括缺氧，营养物质缺乏和代谢产物积聚在内的代谢因子有助于恶性腹水的免疫抑制状态。恶性腹水和卵巢实体瘤表现出不同的代谢特征。在这篇综述中，我们总结了卵巢癌腹水中免疫细胞与代谢因子之间相互作用的最新发现。分析了代谢因子对恶性腹水中T细胞抗肿瘤功能的影响。最后，我们讨论了该领域未来研究的潜在方向。