Synthesis of some oxazolo and oxazinopyrano[3,2‐c]quinolines and their antitumor activity,Journal of Heterocyclic Chemistry

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Synthesis of some oxazolo and oxazinopyrano[3,2‐c]quinolines and their antitumor activity
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-03-24 , DOI: 10.1002/jhet.3963
Dalia Abdel‐Kader ₁ , Mohamed Abass ₁

Affiliation

3‐Amino‐4‐hydroxy‐6‐phenylpyrano[3,2‐c ]quinoline‐2,5(6H )‐dione was produced by a smooth reduction of its nitro precursor. Reaction of this 3‐amino‐4‐hydroxypyranoquinoline derivative with different electrophiles, leading to a variety of oxazolo and oxazinopyrano[3,2‐c ]quinoline derivatives, was described. The structure of the new products was elucidated via elemental analysis, IR, ¹H NMR, ¹³C NMR, and mass spectra. Also, screening the antitumor activity of new compounds against two human cell lines (HepG‐2 and HCT‐116) was carried out. Some new products showed significant antitumor activities.

中文翻译：

某些恶唑啉和恶嗪吡喃并[3,2-c]喹啉的合成及其抗肿瘤活性

3-氨基4-羟基-6-苯基吡喃并[3,2- c ]喹啉-2,5（6 H）-二酮是由其硝基前体的平滑还原制得的。描述了这种3-氨基-4-羟基吡喃喹啉衍生物与不同亲电试剂的反应，导致了各种恶唑啉和恶嗪吡喃并[3,2- c ]喹啉衍生物。通过元素分析，IR，¹ H NMR，¹³ C NMR和质谱阐明了新产品的结构。此外，还筛选了新化合物对两种人类细胞系（HepG-2和HCT-116）的抗肿瘤活性。一些新产品显示出显着的抗肿瘤活性。

更新日期：2020-03-24

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