A Facile Approach to Carbon Dots‐Mesoporous Silica Nanohybrids and Their Applications for Multicolor and Two‐Photon Imaging Guided Chemo‐/Photothermal Synergistic Oncotherapy,ChemNanoMat

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A Facile Approach to Carbon Dots‐Mesoporous Silica Nanohybrids and Their Applications for Multicolor and Two‐Photon Imaging Guided Chemo‐/Photothermal Synergistic Oncotherapy
ChemNanoMat ( IF 2.6 ) Pub Date : 2020-04-14 , DOI: 10.1002/cnma.202000101
Shan Sun ₁ , Shuai Zhao _{1,

2} , Kai Jiang ₁ , Yuhui Wang ₁ , Qinghai Shu ₂ , Shaohua Jin ₂ , Zhongjun Li ₃ , Hengwei Lin _{1,

4}

Affiliation

Multifunctional nanocarrier‐based theranostics have been proposed to overcome some key problems in cancer treatments. In this contribution, a facile approach is reported to synthesize carbon dots‐mesoporous silica nanohybrids (named MSNs‐CDs) via a one‐pot microwave heating reaction of amino‐functionalized mesoporous silica nanoparticles (MSNs‐NH₂) and citric acid in formamide. The MSNs‐CDs nanohybrids exhibit capabilities of multicolor/two‐photon imaging, high photothermal conversion under NIR laser irradiation (671 nm), and anti‐cancer drug delivery, and thus could potentially be applied as a multifunctional nanocarrier‐based theranostic agent for cancer. Further studies revealed that CDs were in situ formed on the surface of MSNs during the reaction, which is amenable for the observed multicolor/two‐photon imaging and photothermal properties. Besides, the well‐preserved MSNs characters of MSNs‐CDs nanohybrids (e. g., mesoporous structure, large surface area and pore volume) enable them to be an ideal nanocarrier for delivering anti‐cancer drugs, such as doxorubicin (DOX). Importantly, the MSNs‐CDs@DOX exhibited pH‐ (lower pH being preferred) and thermo‐responsive DOX release behaviors, which would effectively decrease side effects and meanwhile enhance the efficacy of chemotherapy due to the weak acidic microenvironment of tumor and photothermal effect of the CDs. Finally, in vitro experiments exhibited that the highest therapeutic efficacy was obtained by MSNs‐CDs@DOX with NIR irradiation, attributing to the synergistic effect of chemotherapy and PTT. This study not only provides a facile method to prepare CDs and MSNs nanohybrids, but also demonstrates that both of the superior features and functions of CDs and MSNs could be preserved and combined, which are deemed to be beneficial for the development of multifunctional theranostic nanoplatform for cancers.

中文翻译：

碳点介孔二氧化硅纳米杂化物的简便方法及其在多色和双光子成像引导的化学/光热协同肿瘤治疗中的应用

已经提出了基于多功能纳米载体的治疗方法，以克服癌症治疗中的一些关键问题。在这一贡献中，据报道，一种简便的方法是通过氨基官能化介孔二氧化硅纳米粒子（MSNs-NH ₂）的一锅微波加热反应来合成碳点-中孔二氧化硅纳米杂化物（称为MSNs-CD）。）和柠檬酸中的甲酰胺。MSNs-CDs纳米杂化物具有多色/双光子成像，在NIR激光辐照（671 nm）下具有高光热转换和抗癌药物递送的能力，因此有可能被用作基于多功能纳米载体的治疗剂。进一步的研究表明，在反应过程中，MSNs表面原位形成了CD，这适用于观察到的多色/双光子成像和光热性质。此外，MSNs-CDs纳米杂化物保存完好的MSNs特性（例如，中孔结构，大表面积和孔体积）使它们成为递送抗癌药物（如阿霉素（DOX））的理想纳米载体。重要的是，MSNs-CDs @ DOX表现出pH（优选较低的pH）和热响应DOX释放行为，由于弱酸性的肿瘤微环境和CD的光热作用，可有效减少副作用并同时增强化疗效果。最后，体外实验表明，MSNs-CDs @ DOX结合NIR照射可获得最高的治疗效果，这归因于化学疗法和PTT的协同作用。这项研究不仅提供了一种制备CD和MSNs纳米杂交体的简便方法，而且还证明了CD和MSNs的优越特性和功能都可以保留和结合，这被认为有利于开发多功能的治疗性纳米平台。癌症。

更新日期：2020-04-14

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