Bifunctional Phosphonium Salt‐catalyzed Enantioselective [4+2] Annulation of Isoindigos with Allenes: Access to Complex Heterocycles with Centerpiece of 4H‐Pyrans,Advanced Synthesis & Catalysis

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Bifunctional Phosphonium Salt‐catalyzed Enantioselective [4+2] Annulation of Isoindigos with Allenes: Access to Complex Heterocycles with Centerpiece of 4H‐Pyrans
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-03-24 , DOI: 10.1002/adsc.202000150
Juan Du ₁ , Jia‐Hong Wu ₁ , Lixiang Zhu ₁ , Xiaoyu Ren ₁ , Chunhui Jiang ₂ , Tianli Wang ₁

Affiliation

Structurally fused heterocycles encompassing 4H ‐pyran centerpiece are prevalent scaffolds with promising biological activities, but have daunting synthetic challenges. Herein, we presented a regio‐ and stereoselective [4+2] annulation of isoindigo derivatives with allenes by bifunctional phosphonium catalysis. This protocol provides a complementary way for accessing complex heterocyclic compounds.

中文翻译：

双官能os盐催化的对映异构体[4 + 2]与异烯的环糊精的合成：以4H-吡喃为核心的复杂杂环的获得

包含4 H-吡喃核心的结构稠合杂环是具有前途生物学活性的普遍支架，但在合成方面却面临艰巨挑战。在这里，我们介绍了通过双功能presented催化的异靛蓝衍生物与烯丙基的区域和立体选择性[4 + 2]环化反应。该协议为访问复杂的杂环化合物提供了一种补充方法。

更新日期：2020-03-24

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