Ru‐Catalyzed Sequential Dehydrogenative Friedlander Reaction/sp3 C–H Activation/Knovenagel Condensation in the Regioselective Synthesis of Chimanine B Analogues,European Journal of Organic Chemistry

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Ru‐Catalyzed Sequential Dehydrogenative Friedlander Reaction/sp3 C–H Activation/Knovenagel Condensation in the Regioselective Synthesis of Chimanine B Analogues
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-03-25 , DOI: 10.1002/ejoc.202000201
Soda Prameela ₁ , Fazlur-Rahman Nawaz Khan ₁

Affiliation

DES‐assisted synthesis of Chimanine B analogues (4) was achieved through Ru catalyzed dehydrogenation in K₂CO₃:Glycerol (1:1) and sequential sp³ C–H functionalization via Friendlande reaction in Ch‐Cl:Oxalic acid(1:1). Moreover, Knovenagel condensed product of Chimanine B analogues (5) was achieved by using KOH as base in Ch‐Cl:Oxalic acid (1:1)

中文翻译：

Ru催化顺序脱氢Friedlander反应/ sp3 C–H活化/ Knovenagel缩合反应在Chimanine B类似物的区域选择性合成中的作用。

DES辅助的Chimanine B类似物（4）的合成通过Ru在K ₂ CO ₃：甘油中的催化脱氢（1：1）和在Ch‐Cl：草酸中通过Friendlande反应进行的连续sp ³ C–H官能化（1： 1）。此外，通过在Ch‐Cl：草酸（1：1）中使用KOH作为碱，获得了Chimanine B类似物（5）的Knovenagel缩合产物。

更新日期：2020-03-25

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