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Pseudopericyclic Dearomative 1,6‐Cyclization of 1‐(2‐Pyridyl)‐2‐azabuta‐1,3‐dienes: Synthesis and Ring–Chain Valence Equilibria of 4H‐Pyrido[1,2‐a]pyrazines
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-03-25 , DOI: 10.1002/ejoc.202000210
Ilya P. Filippov 1 , Mikhail S. Novikov 1 , Alexander F. Khlebnikov 1 , Nikolai V. Rostovskii 1
Affiliation  

The 1,6‐electrocyclization of 1‐(2‐pyridyl)‐2‐azabuta‐1,3‐dienes, obtained by RhII‐catalyzed reaction of pyridotriazoles with 2H‐azirines, affords stable non‐aromatic 4H‐pyrido[1,2‐a]pyrazines despite the fact that the reaction proceeds with irreversible dearomatization of the pyridine aromatic system.
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中文翻译:

1-(2-吡啶基)-2-azabuta-1,3-二烯的伪环脱芳香基1,6-环化:4H-吡啶并[1,2-a]吡嗪的合成和环链价平衡

通过Rh II催化的吡啶三唑与2 H叠氮基的反应获得的1-(2-吡啶基)-2-azabuta-1,3-二烯的1,6-电环化可提供稳定的非芳族4 H吡啶基[ 1,2- a ]吡嗪,尽管该反应会随着吡啶芳族体系的不可逆脱芳香化而进行。
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更新日期:2020-03-25
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