Release of silver from nanoparticle-based filter paper and the impacts to mouse gut microbiota,Environmental Science: Nano

当前位置： X-MOL 学术 › Environ. Sci.: Nano › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Release of silver from nanoparticle-based filter paper and the impacts to mouse gut microbiota
Environmental Science: Nano ( IF 5.8 ) Pub Date : 2020-03-25 , DOI: 10.1039/c9en01387c
Jingtao Wu _{1,

2,

3,

4} , Cui Li _{1,

2,

3,

4,

5} , Jie Zhang _{1,

2,

3,

4} , Neal W. Menzies _{1,

2,

3,

4} , Paul M. Bertsch _{1,

2,

3,

4,

6} , Peng Wang _{7,

8,

9,

10} , Peter M. Kopittke _{1,

2,

3,

4}

Affiliation

Filtration products containing silver nanoparticles (Ag-NPs) have been used for water purification to provide drinking water for humans. However, it is unclear if differences in water chemistry influence their effectiveness or whether the presence of Ag in the filtrate (drinking water) impacts the gut microbiome. Using water samples differing markedly in chemical properties, we have found that ≥99.89% of E. coli were killed in all cases, regardless of the water chemistry. However, in the first 25 mL of filtration, concentrations of Ag in most of the water samples (0.14–45.2 mg L⁻¹) exceeded the limit for drinking water (0.1 mg L⁻¹), differing depending upon water chemistry. Synchrotron-based X-ray absorption spectroscopy analysis revealed that up to 36% of the Ag in the filter paper was present as AgNO₃ and 64% as Ag-NPs, with this AgNO₃ likely contributing to the high Ag concentrations in the filtrate. Finally, we also examined the impacts of oral gavage of the Ag-containing filtrate on the mouse gut microbiome. It was found that Ag from the filtrate accumulated mainly in the liver and kidneys. In female mice, we also found that the Ag-containing filtrate increased the relative abundance of Bacteroidetes in the faeces, whilst decreasing that of Firmicutes. Our data indicate that although Ag-NP-containing filter products have excellent antimicrobial properties, the high concentrations of Ag in the filtrate are potentially of concern for the gut microbiome and further work is required in this regard.

中文翻译：

纳米颗粒滤纸中银的释放及其对小鼠肠道菌群的影响

含有银纳米颗粒（Ag-NPs）的过滤产品已用于水净化，以为人类提供饮用水。但是，尚不清楚水化学差异是否会影响其有效性，或者滤液（饮用水）中Ag的存在是否会影响肠道微生物组。使用化学性质明显不同的水样本，我们发现在所有情况下，≥99.89％的大肠杆菌都被杀死，而与水的化学性质无关。但是，在最初的25 mL过滤中，大多数水样中的Ag浓度（0.14–45.2 mg L ^-1）超过了饮用水的限值（0.1 mg L ^-1），具体取决于水的化学性质。基于同步加速器的X射线吸收光谱分析表明，滤纸中高达36％的Ag以AgNO _3的形式存在，而64％以Ag-NP的形式存在，这种AgNO ₃可能有助于滤液中高的Ag浓度。最后，我们还检查了管饲含银滤液对小鼠肠道微生物组的影响。发现滤液中的Ag主要积累在肝和肾中。在雌性小鼠中，我们还发现含银的滤液增加了粪便中拟杆菌的相对丰度，同时降低了Fimicutes的相对丰度。。我们的数据表明，尽管含Ag-NP的过滤产品具有出色的抗菌性能，但肠道微生物组可能会关注滤液中高浓度的Ag，因此需要进一步的研究。

更新日期：2020-03-25

点击分享查看原文

点击收藏

阅读更多本刊最新论文