Temperature cross-sensitivity is a long-standing challenge for most of the in-line fiber optofluidic waveguide biosensors. In this paper, we propose a dual-optofluidic waveguide antiresonant reflecting optical waveguide (ARROW) biosensor for the detection of interferon-gamma (IFN-γ) concentration with temperature compensation. Two Fabry-Perot resonators infiltrated with IFN-γ and NaCl were formed in a hollow core fiber, which generate two resonance dips based on the ARROW model. The optical biosensor for the detection of interferon-gamma (IFN-γ) has been a key research interest in recent years because IFN-γ is an important early biomarker for many serious human diseases. Based on the dual-optofluidic waveguide ARROW biosensor, the IFN-γ concentration can be measured through the modulation of the resonance condition of the ARROW, while the temperature fluctuation can be eliminated due to same thermo-optic coefficients of two infiltration liquids. The experimental results show that the response of the ARROW biosensor can be amplified significantly with the signal-enhanced streptavidin, and the limit of detection of 0.5 ng/ml can be achieved for the IFN-γ concentration. More importantly, the influence of the temperature could be compensated through the referenced resonance dip. The proposed fiber biosensor has a great potential for the real-time detection of IFN-γ concentrations in the fields of health monitoring, cancer prevention, biological engineering, etc.

中文翻译：

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双光导波导在线纤维生物传感器，用于带温度补偿的干扰素-γ实时无标签检测

对于大多数在线光纤光流体波导生物传感器而言，温度交叉敏感性是一个长期的挑战。在本文中，我们提出了一种双光流体波导反共振反射光波导（ARROW）生物传感器，用于通过温度补偿来检测干扰素-γ（IFN-γ）的浓度。在空心光纤中形成了两个浸有IFN-γ和NaCl的Fabry-Perot谐振器，它们根据ARROW模型产生了两个谐振谷。近年来，用于检测干扰素-γ（IFN-γ）的光学生物传感器已成为研究的重点，因为IFN-γ是许多严重人类疾病的重要早期生物标记。基于双光波导ARROW生物传感器，可以通过调节ARROW的共振条件来测量IFN-γ浓度，同时由于两种渗透液体的相同热光系数，可以消除温度波动。实验结果表明，信号增强的抗生蛋白链菌素可显着增强ARROW生物传感器的响应，且IFN-γ浓度的检测限可达到0.5 ng / ml。更重要的是，温度的影响可以通过参考谐振骤降来补偿。所提出的纤维生物传感器在健康监测，癌症预防，生物工程等领域具有实时检测IFN-γ浓度的巨大潜力。实验结果表明，信号增强的抗生蛋白链菌素可显着增强ARROW生物传感器的响应，且IFN-γ浓度的检测限可达到0.5 ng / ml。更重要的是，温度的影响可以通过参考谐振骤降来补偿。所提出的纤维生物传感器在健康监测，癌症预防，生物工程等领域具有实时检测IFN-γ浓度的巨大潜力。实验结果表明，信号增强的抗生蛋白链菌素可显着增强ARROW生物传感器的响应，且IFN-γ浓度的检测限可达到0.5 ng / ml。更重要的是，温度的影响可以通过参考谐振骤降来补偿。所提出的纤维生物传感器在健康监测，癌症预防，生物工程等领域具有实时检测IFN-γ浓度的巨大潜力。