US nativity and dietary acculturation impact the gut microbiome in a diverse US population.,The ISME Journal

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US nativity and dietary acculturation impact the gut microbiome in a diverse US population.
The ISME Journal ( IF 10.8 ) Pub Date : 2020-03-24 , DOI: 10.1038/s41396-020-0630-6
Brandilyn A Peters _{1,

2} , Stella S Yi ₁ , Jeannette M Beasley ₃ , Emilia N Cobbs ₁ , Hee Sun Choi ₁ , Dia B Beggs ₁ , Richard B Hayes _{1,

4} , Jiyoung Ahn _{1,

4}

Affiliation

Little is known regarding the impact of immigrant acculturation on the gut microbiome. We characterized differences in the gut microbiome between racially/ethnically diverse US immigrant and US-born groups, and determined the impact of dietary acculturation on the microbiome. Stool samples were collected from 863 US residents, including US-born (315 White, 93 Black, 40 Hispanic) and foreign-born (105 Hispanic, 264 Korean) groups. We determined dietary acculturation from dissimilarities based on food frequency questionnaires, and used 16S rRNA gene sequencing to characterize the microbiome. Gut microbiome composition differed across study groups, with the largest difference between foreign-born Koreans and US-born Whites, and significant differences also observed between foreign-born and US-born Hispanics. Differences in sub-operational taxonomic unit (s-OTU) abundance between foreign-born and US-born groups tended to be distinct from differences between US-born groups. Bacteroides plebeius, a seaweed-degrading bacterium, was strongly enriched in foreign-born Koreans, while Prevotella copri and Bifidobacterium adolescentis were strongly enriched in foreign-born Koreans and Hispanics, compared with US-born Whites. Dietary acculturation in foreign-born participants was associated with specific s-OTUs, resembling abundance in US-born Whites; e.g., a Bacteroides plebeius s-OTU was depleted in highly diet-acculturated Koreans. In summary, we observed that US nativity is a determinant of the gut microbiome in a US resident population. Dietary acculturation may result in loss of native species in immigrants, though further research is necessary to explore whether acculturation-related microbiome alterations have consequences for immigrant health.

中文翻译：

美国出生和饮食文化适应影响美国不同人群的肠道微生物组。

关于移民文化适应对肠道微生物组的影响知之甚少。我们描述了种族/民族多样化的美国移民和美国出生群体之间肠道微生物组的差异，并确定了饮食文化适应对微生物组的影响。从 863 名美国居民那里收集了粪便样本，包括美国出生的（315 名白人、93 名黑人、40 名西班牙裔）和外国出生的（105 名西班牙裔、264 名韩国人）群体。我们根据食物频率问卷确定饮食文化差异，并使用 16S rRNA 基因测序来表征微生物组。不同研究组的肠道微生物组组成不同，在外国出生的韩国人和在美国出生的白人之间差异最大，在外国出生和在美国出生的西班牙裔之间也观察到显着差异。外国出生和美国出生的群体之间的子操作分类单位 (s-OTU) 丰度的差异往往不同于美国出生的群体之间的差异。Bacteroides plebeius 是一种海藻降解细菌，在外国出生的韩国人中高度富集，而与美国出生的白人相比，普雷沃氏菌和青春双歧杆菌在外国出生的韩国人和西班牙裔中高度富集。外国出生的参与者的饮食文化适应与特定的 s-OTU 相关，类似于美国出生的白人的丰富度；例如，一种拟杆菌属 plebeius s-OTU 在高度饮食适应的韩国人中被耗尽。总之，我们观察到美国出生是美国常住人口肠道微生物组的决定因素。饮食文化适应可能导致移民中本地物种的丧失，

更新日期：2020-03-24

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