Dietary modifications for enhanced cancer therapy,Nature

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Dietary modifications for enhanced cancer therapy
Nature ( IF 50.5 ) Pub Date : 2020-03-01 , DOI: 10.1038/s41586-020-2124-0
Naama Kanarek _{1,

2,

3} , Boryana Petrova ₁ , David M Sabatini _{3,

4,

5,

6}

Affiliation

Tumours depend on nutrients supplied by the host for their growth and survival. Modifications to the host’s diet can change nutrient availability in the tumour microenvironment, which might represent a promising strategy for inhibiting tumour growth. Dietary modifications can limit tumour-specific nutritional requirements, alter certain nutrients that target the metabolic vulnerabilities of the tumour, or enhance the cytotoxicity of anti-cancer drugs. Recent reports have suggested that modification of several nutrients in the diet can alter the efficacy of cancer therapies, and some of the newest developments in this quickly expanding field are reviewed here. The results discussed indicate that the dietary habits and nutritional state of a patient must be taken into account during cancer research and therapy.

中文翻译：

加强癌症治疗的饮食调整

肿瘤的生长和生存依赖于宿主提供的营养。改变宿主的饮食可以改变肿瘤微环境中的营养供应，这可能代表了一种有前途的抑制肿瘤生长的策略。饮食调整可以限制肿瘤特定的营养需求，改变某些针对肿瘤代谢脆弱性的营养物质，或增强抗癌药物的细胞毒性。最近的报告表明，改变饮食中的几种营养素可以改变癌症治疗的效果，这里将回顾这个快速发展的领域的一些最新进展。讨论的结果表明，在癌症研究和治疗期间必须考虑患者的饮食习惯和营养状况。

更新日期：2020-03-01

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