Prenatal and perinatal complications in the development of psychosis: canaries in the coalmine.,The Lancet Psychiatry

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Prenatal and perinatal complications in the development of psychosis: canaries in the coalmine.
The Lancet Psychiatry ( IF 30.8 ) Pub Date : 2020-03-24 , DOI: 10.1016/s2215-0366(20)30095-x
Mary Cannon ₁ , Colm Healy ₁ , Mary C Clarke ₂ , David Cotter ₁

Affiliation

Although first suggested as early as the 1930s, the study of obstetric complications as risk factors for later psychotic disorders came to the fore in the late 1980s, when proponents of the neurodevelopmental aetiological model of schizophrenia cited the association between obstetric adversity and later schizophrenia as an essential building block for this theoretical approach. A meta-analytic review of this literature in 2002 concluded that no specific obstetric complications were associated with schizophrenia– rather a host of prenatal and perinatal risk factors of small effect size (typically with odds ratios [ORs] of less than 2).

中文翻译：

精神病发展中的产前和围产期并发症：煤矿中的金丝雀。

尽管最早在1930年代就提出了建议，但在1980年代后期，对精神分裂症的神经发育病因学模型的支持者将产科逆境与后来的精神分裂症之间的联系作为研究的重点，对作为以后精神病性疾病的危险因素的产科并发症的研究开始兴起。这种理论方法的基本组成部分。2002年对该文献进行的荟萃分析总结认为，精神分裂症没有特定的产科并发症，而是许多影响大小较小的产前和围产期危险因素（通常比值比[OR]小于2）。

更新日期：2020-03-26

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