Patients are turning into herbs for the management of diabetes, which cause increasing in the demand of plant-based alternative medicines. Ficus deltoidea or locally known as “Mas Cotek” in Malaysia is a famous herbal plant. However, many varieties of F. deltoidea existed with varied antidiabetic activities inspire us to evaluate in vivo antidiabetic activity of the most available varieties of F. deltoidea. Therefore, antihyperglycemic effect of different varieties of F. deltoidea at dose 250 mg/kg was evaluated on streptozotocin-nicotinamide–induced diabetic rats and further assessed their urinary metabolites using proton nuclear magnetic resonance (¹H-NMR). The hyperglycemic blood level improved towards normoglycemic state after 30 days of treatment with standardized extracts of F. deltoidea var. trengganuensis, var. kunstleri, and var. intermedia. The extracts also significantly managed the biochemical parameters in diabetic rats. Metabolomics results showed these varieties were able to manage the altered metabolites of diabetic rats by shifting some of the metabolites back to their normal state. This knowledge might be very important in suggesting the use of these herbs in long-term treatment for diabetes. The most potential variety can be recommended, which may be useful for further pharmacological studies and herbal authentication processes.

患者正在变成治疗糖尿病的草药，这导致对基于植物的替代药物的需求增加。榕树（Ficus deltoidea）或在马来西亚当地称为“ Mas Cotek”是著名的草药植物。然而，许多品种的F. deltoidea与变化，抗糖尿病活性激励我们最可用的品种体内抗糖尿病活性评价存在F. deltoidea。因此，在链脲佐菌素-烟酰胺诱导的糖尿病大鼠上评估了不同品种百日咳杆菌的250 mg / kg的降血糖作用，并通过质子核磁共振进一步评估了它们的尿代谢产物（¹1 H-NMR）。用标准的F. deltoidea var提取物治疗30天后，高血糖血液水平朝着正常血糖状态改善。trengganuensis，VAR。kunstleri和var。中间媒体。提取物还显着控制了糖尿病大鼠的生化指标。代谢组学结果表明，这些品种能够通过将某些代谢物恢复至正常状态来管理糖尿病大鼠的代谢物改变。这些知识对于建议将这些草药用于糖尿病的长期治疗中可能非常重要。可以建议最有潜力的品种，这可能对进一步的药理研究和草药鉴定过程有用。