The relationship between diet and cancer is often viewed with skepticism by the public and health professionals, despite a considerable body of evidence and general consistency in recommendations over the past decades. A systems biology approach which integrates ‘omics’ data including metabolomics, genetics, metagenomics, transcriptomics and proteomics holds promise for developing a better understanding of how diet affects cancer and for improving the assessment of diet through biomarker discovery thereby renewing confidence in diet–cancer links. This review discusses the application of multi-omics approaches to studies of diet and cancer. Considerations and challenges that need to be addressed to facilitate the investigation of diet–cancer relationships with multi-omic approaches are also discussed.

中文翻译：

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评估饮食与癌症关系的综合方法。

尽管过去几十年来有大量的证据和建议的总体一致性，但公众和卫生专业人员常常怀疑饮食与癌症之间的关系。系统生物学方法整合了包括代谢组学，遗传学，宏基因组学，转录组学和蛋白质组学在内的“组学”数据，有望更好地了解饮食对癌症的影响，并通过发现生物标记物改善饮食评估，从而重新树立饮食与癌症联系的信心。这篇综述讨论了多组学方法在饮食和癌症研究中的应用。还讨论了必须解决的问题和挑战，以利于采用多组学方法研究饮食与癌症之间的关系。