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Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive V{gamma}9V{delta}2 T cell subset [Immunology and Inflammation]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2020-03-24
Alina S. Fichtner, Mohindar M. Karunakaran, Siyi Gu, Christopher T. Boughter, Marta T. Borowska, Lisa Starick, Anna Nohren, Thomas W. Gobel, Erin J. Adams, Thomas Herrmann

Vγ9Vδ2 T cells are a major γδ T cell population in the human blood expressing a characteristic Vγ9JP rearrangement paired with Vδ2. This cell subset is activated in a TCR-dependent and MHC-unrestricted fashion by so-called phosphoantigens (PAgs). PAgs can be microbial [(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate, HMBPP] or endogenous (isopentenyl pyrophosphate, IPP) and...

中文翻译:

羊驼(Vicugna pacos),第一个具有磷酸抗原反应性V {gamma} 9V {delta} 2 T细胞亚群的非灵长类动物[免疫学和炎症]

Vγ9Vδ2T细胞是人血中主要的γδT细胞,表达与Vδ2配对的特征性Vγ9JP重排。该细胞亚群被所谓的磷酸抗原(PAgs)以TCR依赖性和MHC无限制的方式激活。PAgs可以是微生物[[E] -4-羟基-3-甲基-丁-2-烯基焦磷酸盐,HMBPP]或内源性(异戊烯基焦磷酸盐,IPP)和...
更新日期:2020-03-26
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