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Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive V{gamma}9V{delta}2 T cell subset [Immunology and Inflammation]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2020-03-24 Alina S. Fichtner, Mohindar M. Karunakaran, Siyi Gu, Christopher T. Boughter, Marta T. Borowska, Lisa Starick, Anna Nohren, Thomas W. Gobel, Erin J. Adams, Thomas Herrmann
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2020-03-24 Alina S. Fichtner, Mohindar M. Karunakaran, Siyi Gu, Christopher T. Boughter, Marta T. Borowska, Lisa Starick, Anna Nohren, Thomas W. Gobel, Erin J. Adams, Thomas Herrmann
Vγ9Vδ2 T cells are a major γδ T cell population in the human blood expressing a characteristic Vγ9JP rearrangement paired with Vδ2. This cell subset is activated in a TCR-dependent and MHC-unrestricted fashion by so-called phosphoantigens (PAgs). PAgs can be microbial [(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate, HMBPP] or endogenous (isopentenyl pyrophosphate, IPP) and...
中文翻译:
羊驼(Vicugna pacos),第一个具有磷酸抗原反应性V {gamma} 9V {delta} 2 T细胞亚群的非灵长类动物[免疫学和炎症]
Vγ9Vδ2T细胞是人血中主要的γδT细胞,表达与Vδ2配对的特征性Vγ9JP重排。该细胞亚群被所谓的磷酸抗原(PAgs)以TCR依赖性和MHC无限制的方式激活。PAgs可以是微生物[[E] -4-羟基-3-甲基-丁-2-烯基焦磷酸盐,HMBPP]或内源性(异戊烯基焦磷酸盐,IPP)和...
更新日期:2020-03-26
中文翻译:
羊驼(Vicugna pacos),第一个具有磷酸抗原反应性V {gamma} 9V {delta} 2 T细胞亚群的非灵长类动物[免疫学和炎症]
Vγ9Vδ2T细胞是人血中主要的γδT细胞,表达与Vδ2配对的特征性Vγ9JP重排。该细胞亚群被所谓的磷酸抗原(PAgs)以TCR依赖性和MHC无限制的方式激活。PAgs可以是微生物[[E] -4-羟基-3-甲基-丁-2-烯基焦磷酸盐,HMBPP]或内源性(异戊烯基焦磷酸盐,IPP)和...