Inefficient physiological transitions are known to cause metabolic disorders. Therefore, investigating mechanisms that constitute molecular switches in a central metabolic organ like the liver becomes crucial. Specifically, upstream mechanisms that control temporal engagement of transcription factors, which are essential to mediate physiological fed–fast–refed transitions are less understood. SIRT1, a NAD+-dependent...

中文翻译：

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O-GlcNAcylation对SIRT1功能的时空选通对于肝脏代谢转换和预防高血糖至关重要[生理学]

已知无效的生理转变会引起代谢紊乱。因此，研究在诸如肝脏的中央新陈代谢器官中构成分子转换的机制变得至关重要。具体地说，人们对于控制转录因子的时间参与的上游机制了解得很少，而这些机制对于介导生理学-快速-参考过渡至关重要。SIRT1，一个与NAD +相关的...