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Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia [Physiology]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.580 ) Pub Date : 2020-03-24
Tandrika Chattopadhyay, Babukrishna Maniyadath, Hema P. Bagul, Arindam Chakraborty, Namrata Shukla, Srikanth Budnar, Abinaya Rajendran, Arushi Shukla, Siddhesh S. Kamat, Ullas Kolthur-Seetharam

Inefficient physiological transitions are known to cause metabolic disorders. Therefore, investigating mechanisms that constitute molecular switches in a central metabolic organ like the liver becomes crucial. Specifically, upstream mechanisms that control temporal engagement of transcription factors, which are essential to mediate physiological fed–fast–refed transitions are less understood. SIRT1, a NAD+-dependent...
更新日期:2020-03-26

 

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